Literature DB >> 300408

Are Actinomyces viscosus antigens B cell mitogens?

J J Burckhardt, B Guggenheim, A Hefti.   

Abstract

An extracellular heteroglycan (ECHG) and a sonicated cell supernatant (SCS) of Actinomyces viscosus Ny 1 induced strong lymphocyte proliferation. This was shown with spleen and thoracic duct cells form germfree rats and confirmed with cells from conventional "nude" mouse spleens. Spleen cells developed direct plaque-forming cells against densely coupled TNP-SRBC. The mitogenic property of ECHG was diminished considerably after mild alkaline hydrolysis for lymphocytes form rat spleens and was totally abolished for cells from "nude" mouse spleens. These results suggest that ECHG and SCS have B cell mitogenicity.

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Year:  1977        PMID： 300408

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  17 in total

Review 1.  Polyclonal activators in pulmonary immune disease.

Authors:  W F Willoughby; J B Willoughby; G F Gerberick
Journal:  Clin Rev Allergy       Date:  1985-05

2.  Activation of human T-lymphocytes. A kinetic and stereological study.

Authors:  G E Petrzilka; H E Schroeder
Journal:  Cell Tissue Res       Date:  1979-09-02       Impact factor: 5.249

3.  Identification and distribution of immunocompetent cells in inflamed gingiva of human chronic periodontitis.

Authors:  H Okada; T Kida; H Yamagami
Journal:  Infect Immun       Date:  1983-07       Impact factor: 3.441

4.  Polyclonal B-cell activation induced by extracts of Gram-negative bacteria isolated from periodontally diseased sites.

Authors:  P H Bick; A B Carpenter; L V Holdeman; G A Miller; R R Ranney; K G Palcanis; J G Tew
Journal:  Infect Immun       Date:  1981-10       Impact factor: 3.441

5.  Cyclosporin A: in vivo and in vitro suppression of rat T-lymphocyte function.

Authors:  J J Burckhardt; B Guggenheim
Journal:  Immunology       Date:  1979-04       Impact factor: 7.397

6.  In vitro stimulation of immunoglobulin production from human peripheral blood lymphocytes by a soluble preparation of Actinomyces viscosus.

Authors:  D F Mangan; D E Lopatin
Journal:  Infect Immun       Date:  1981-01       Impact factor: 3.441

7.  Cell-mediated cytotoxicity against rat fibroblasts induced by Actinomyces viscosus.

Authors:  R Gaegauf-Zollinger; J J Burckhardt; R Gmür; B Guggenheim
Journal:  Infect Immun       Date:  1982-08       Impact factor: 3.441

8.  Comparative histopathology of lesions produced by Actinomyces israelii, Actinomyces naeslundii, and Actinomyces viscosus in mice.

Authors:  M J Behbehani; J D Heeley; H V Jordan
Journal:  Am J Pathol       Date:  1983-03       Impact factor: 4.307

9.  Role of macrophages in the lymphocyte response to Actinomyces viscosus.

Authors:  R M McCarron; J E Fitzgerald; D C Birdsell
Journal:  Infect Immun       Date:  1982-11       Impact factor: 3.441

10.  Effects of an immunomodulating agent on peripheral blood lymphocytes and subgingival microflora in ligature-induced periodontitis.

Authors:  F Manti; K Kornman; I Goldschneider
Journal:  Infect Immun       Date:  1984-07       Impact factor: 3.441
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