Amanda Douglass1,2, Mark Walterfang3,4,5, Dennis Velakoulis3,4, Larry Abel1. 1. Department of Optometry and Vision Sciences, The University of Melbourne, Melbourne, Australia. 2. Department of Optometry, Deakin University, Waurn Ponds, Australia. 3. Department of Psychiatry, The University of Melbourne, Melbourne, Australia. 4. Neuropsychiatry Unit, Royal Melbourne Hospital, Melbourne, Australia. 5. Florey Institute of Neuroscience and Mental Health, Melbourne, Australia.
Abstract
BACKGROUND: Saccadic paradigms display changes across a number of degenerative conditions reflecting changes in the oculomotor pathway which in some conditions have been linked to disease presentation. OBJECTIVE: To examine a novel range of saccadic paradigms in behavioral variant frontotemporal dementia (bvFTD). METHODS: Prosaccade, predictive, self-paced, memory-guided, and anti-saccade tasks were examined in bvFTD patients and controls. RESULTS: A significant increase in latency for the bvFTD group was seen in all tasks. Self-paced saccades are reduced in number, memory-guided saccades display an increase in errors. Predictive saccades show an increased latency that does not remain when prosaccade latency changes are accounted for. While changes were seen across a range of paradigms, no individual task completely separated bvFTD from control participants. CONCLUSION: bvFTD patients as a group display a number of changes on saccadic testing which may reflect the frontal lobe changes seen in this condition.
BACKGROUND: Saccadic paradigms display changes across a number of degenerative conditions reflecting changes in the oculomotor pathway which in some conditions have been linked to disease presentation. OBJECTIVE: To examine a novel range of saccadic paradigms in behavioral variant frontotemporal dementia (bvFTD). METHODS:Prosaccade, predictive, self-paced, memory-guided, and anti-saccade tasks were examined in bvFTDpatients and controls. RESULTS: A significant increase in latency for the bvFTD group was seen in all tasks. Self-paced saccades are reduced in number, memory-guided saccades display an increase in errors. Predictive saccades show an increased latency that does not remain when prosaccade latency changes are accounted for. While changes were seen across a range of paradigms, no individual task completely separated bvFTD from control participants. CONCLUSION:bvFTDpatients as a group display a number of changes on saccadic testing which may reflect the frontal lobe changes seen in this condition.
Authors: Lucy L Russell; Caroline V Greaves; Rhian S Convery; Jennifer Nicholas; Jason D Warren; Diego Kaski; Jonathan D Rohrer Journal: Alzheimers Res Ther Date: 2021-02-08 Impact factor: 6.982
Authors: Lucy L Russell; Caroline V Greaves; Rhian S Convery; Martina Bocchetta; Jason D Warren; Diego Kaski; Jonathan D Rohrer Journal: Alzheimers Dement (N Y) Date: 2021-12-31