Wen Wang1,2, Dazhi Fan1,2,3, Jun Wang4, Shuzhen Wu1,2, Ying Lu5,6, Yunying He1, Zhengping Liu1,2. 1. a Department of Obstetrics , Southern Medical University Affiliated Maternal and Child Health Hospital of Foshan , Foshan , Guangdong , China. 2. b Foshan Institute of Fetal Medicine , Southern Medical University Affiliated Maternal & Child Health Hospital of Foshan , Foshan , Guangdong , China. 3. c Department of Epidemiology and Biostatistics , School of Public Health, Anhui Medical University , Hefei , Anhui , China. 4. d Department of Obstetrics , Anhui Medical University Affiliated the Second Provincial Hospital , Hefei , Anhui , China. 5. e Department of Communicable Disease Control and Prevention , Guangzhou centre for disease control and prevention , Guangzhou , Guangdong , China. 6. f Department of Epidemiology and Biostatistics , School of Public Health, Sun yat-sen University , Guangzhou , Guangdong , China.
Abstract
OBJECTIVE: Previous studies have reported a positive association between hypertensive disorders complicating pregnancy and placenta accreta. However, whether hypertensive disorders complicating pregnancy associated with placenta accreta is still not clear. The objective was to systematically review the literature to determine a possible association between hypertensive disorders complicating pregnancy and placenta accreta. METHODS: A systematic search of PubMed database, the Cochrane Library, Willy Online Library, and ScienceDirect database through 1st December 2015, was conducted. Two authors independently assessed data extraction and quality of the studies using the Newcastle-Ottawa Scale. Assessment of heterogeneity and analysis of data were operated by Review Manager 5.3.0. RESULTS: Three studies involving 4174 patients who developed hypertensive disorders complicating pregnancy of a total of 38,004 pregnant women were selected. The result of our meta-analysis revealed that pregnancy induced hypertension was significantly associated with a reduction of placenta accreta (OR = 0.50, 95% CI: 0.30-0.82; heterogeneity: I2 = 13%, p = 0.32). CONCLUSIONS: Our meta-analysis demonstrated that the risk of placenta accreta is reduced in women with hypertensive disorders complicating pregnancy. Further well-designed studies are warranted to testify the result and explored any potential mechanism association between hypertensive disorders complicating pregnancy and placenta accreta.
OBJECTIVE: Previous studies have reported a positive association between hypertensive disorders complicating pregnancy and placenta accreta. However, whether hypertensive disorders complicating pregnancy associated with placenta accreta is still not clear. The objective was to systematically review the literature to determine a possible association between hypertensive disorders complicating pregnancy and placenta accreta. METHODS: A systematic search of PubMed database, the Cochrane Library, Willy Online Library, and ScienceDirect database through 1st December 2015, was conducted. Two authors independently assessed data extraction and quality of the studies using the Newcastle-Ottawa Scale. Assessment of heterogeneity and analysis of data were operated by Review Manager 5.3.0. RESULTS: Three studies involving 4174 patients who developed hypertensive disorders complicating pregnancy of a total of 38,004 pregnant women were selected. The result of our meta-analysis revealed that pregnancy induced hypertension was significantly associated with a reduction of placenta accreta (OR = 0.50, 95% CI: 0.30-0.82; heterogeneity: I2 = 13%, p = 0.32). CONCLUSIONS: Our meta-analysis demonstrated that the risk of placenta accreta is reduced in women with hypertensive disorders complicating pregnancy. Further well-designed studies are warranted to testify the result and explored any potential mechanism association between hypertensive disorders complicating pregnancy and placenta accreta.