Ying Liang1, Ling-Bo Qu2, Hao Liu3. 1. School of Pharmacy, Guangdong Food and Drug Vocational College, Guangzhou, 510520, Guangdong, China. 2. Department of Chemistry, Zhengzhou University, Zhengzhou, 450052, Henan, China. 3. School of Pharmacy, Guangdong Food and Drug Vocational College, Guangzhou, 510520, Guangdong, China. 1768065467@qq.com.
Abstract
BACKGROUND: Mount evidence from observational studies suggested that associations between sleep duration and the risks of mild cognitive impairment (MCI)/dementia or cognitive decline had been recognized. METHODS: To explore the precise and continuous effect of sleep duration on these risks, we conducted a dose-response meta-analysis to quantitatively assess it. RESULTS: Five prospective cohort studies and 4 cross-sectional studies were eligible for inclusion criteria, which involved 62937 individuals, and documented 2718 MCI/dementia cases and 5596 cognitive decline cases. The pooled RR per 1 h increases in sleep duration was 0.99 (95% CI 0.97-1.01, I2 = 62.40%, P = 0.02, n = 6) for cognitive decline risk, and 0.98 (95% CI 0.97-1.00, I2 = 0%, P = 0.42, n = 4) for MCI/dementia risk. Similar U-shaped non-linear relationship of sleep duration and the risks of MCI/dementia and cognitive decline was revealed, respectively (all Pnon-linearity < 0.001), whose peaks are approximately 7 h. CONCLUSION: In conclusion, 7 h sleep duration tends to acquire the least risk of MCI/dementia or cognitive decline; however, more well-designed randomized controlled trials are urgently needed to balance potential modifiers.
BACKGROUND: Mount evidence from observational studies suggested that associations between sleep duration and the risks of mild cognitive impairment (MCI)/dementia or cognitive decline had been recognized. METHODS: To explore the precise and continuous effect of sleep duration on these risks, we conducted a dose-response meta-analysis to quantitatively assess it. RESULTS: Five prospective cohort studies and 4 cross-sectional studies were eligible for inclusion criteria, which involved 62937 individuals, and documented 2718 MCI/dementia cases and 5596 cognitive decline cases. The pooled RR per 1 h increases in sleep duration was 0.99 (95% CI 0.97-1.01, I2 = 62.40%, P = 0.02, n = 6) for cognitive decline risk, and 0.98 (95% CI 0.97-1.00, I2 = 0%, P = 0.42, n = 4) for MCI/dementia risk. Similar U-shaped non-linear relationship of sleep duration and the risks of MCI/dementia and cognitive decline was revealed, respectively (all Pnon-linearity < 0.001), whose peaks are approximately 7 h. CONCLUSION: In conclusion, 7 h sleep duration tends to acquire the least risk of MCI/dementia or cognitive decline; however, more well-designed randomized controlled trials are urgently needed to balance potential modifiers.
Authors: Robert D Abbott; G Webster Ross; John E Duda; Chol Shin; Jane H Uyehara-Lock; Kamal H Masaki; Lenore J Launer; Lon R White; Caroline M Tanner; Helen Petrovitch Journal: Neurology Date: 2019-08-30 Impact factor: 9.910
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