| Literature DB >> 30039277 |
Francisco Schlottmann1,2, Daniela Molena3, Marco G Patti4,5.
Abstract
The incidence of esophageal adenocarcinoma (EAC) has increased significantly in Western countries. The rising prevalence of gastroesophageal reflux disease (GERD) and obesity has played a major role in the increasing numbers of EAC. Approximately 10-15% of patients with GERD will develop Barrett's esophagus (BE). This metaplastic transformation is due to the chronic injury produced by repeated reflux episodes and involves genetic mutations that can lead to a malignant transformation. Ultimately, the development of EAC is characterized by the sequence BE metaplasia-dysplasia-invasive carcinoma.Entities:
Keywords: Barrett’s esophagus; Esophageal adenocarcinoma; Gastroesophageal reflux disease; High-grade dysplasia; Low-grade dysplasia; Metaplasia
Mesh:
Year: 2018 PMID: 30039277 DOI: 10.1007/s13304-018-0564-y
Source DB: PubMed Journal: Updates Surg ISSN: 2038-131X