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Literature DB >> 3003904

Translocation of protein kinase C activity may mediate hippocampal long-term potentiation.

R F Akers, D M Lovinger, P A Colley, D J Linden, A Routtenberg.

Abstract

Protein kinase C activity in rat hippocampal membranes and cytosol was determined 1 minute and 1 hour after induction of the synaptic plasticity of long-term potentiation. At 1 hour after long-term potentiation, but not at 1 minute, protein kinase C activity was increased twofold in membranes and decreased proportionately in cytosol, suggesting translocation of the activity. This time-dependent redistribution of enzyme activity was directly related to the persistence of synaptic plasticity, suggesting a novel mechanism regulating the strength of synaptic transmission.

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Substances：
Protein Kinase C

Year: 1986 PMID： 3003904 DOI： 10.1126/science.3003904

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

66 in total

1. B-50/GAP-43 phosphorylation and PKC activity are increased in rat hippocampal synaptosomal membranes after an inhibitory avoidance training.

Authors: M Cammarota; G Paratcha; M Levi de Stein; R Bernabeu; I Izquierdo; J H Medina
Journal: Neurochem Res Date: 1997-04 Impact factor: 3.996

2. Developmental lead exposure and two-way active avoidance training alter the distribution of protein kinase C activity in the rat hippocampus.

Authors: H H Chen; T Ma; I A Paul; J L Spencer; I K Ho
Journal: Neurochem Res Date: 1997-09 Impact factor: 3.996

3. Ganglioside inhibition of glutamate-mediated protein kinase C translocation in primary cultures of cerebellar neurons.

Authors: F Vaccarino; A Guidotti; E Costa
Journal: Proc Natl Acad Sci U S A Date: 1987-12 Impact factor: 11.205

10. Localization of the protein kinase C phosphorylation/calmodulin-binding substrate RC3 in dendritic spines of neostriatal neurons.

Authors: J B Watson; J G Sutcliffe; R S Fisher
Journal: Proc Natl Acad Sci U S A Date: 1992-09-15 Impact factor: 11.205

Translocation of protein kinase C activity may mediate hippocampal long-term potentiation.

1. B-50/GAP-43 phosphorylation and PKC activity are increased in rat hippocampal synaptosomal membranes after an inhibitory avoidance training.

2. Developmental lead exposure and two-way active avoidance training alter the distribution of protein kinase C activity in the rat hippocampus.

3. Ganglioside inhibition of glutamate-mediated protein kinase C translocation in primary cultures of cerebellar neurons.

Review 4. Nicotinic modulation of hippocampal cell signaling and associated effects on learning and memory.

Review 5. Synaptic plasticity and phosphorylation.

6. Age-dependent changes in second messenger and rolipram receptor systems in the gerbil brain.

7. Regulation of N-methyl-D-aspartate receptors revealed by intracellular dialysis of murine neurones in culture.

8. A comparison of the roles of protein kinase C in long-term potentiation in rat hippocampal areas CA1 and CA3.

9. Metabotropic glutamate receptors trigger postsynaptic protein synthesis.

10. Localization of the protein kinase C phosphorylation/calmodulin-binding substrate RC3 in dendritic spines of neostriatal neurons.