Clarissa S Craft1,2, Ziru Li3, Ormond A MacDougald3, Erica L Scheller1,2. 1. Division of Bone and Mineral Diseases, Department of Medicine, Washington University, St. Louis, MO, USA. 2. Department of Cell Biology & Physiology, Washington University, St. Louis, MO, USA. 3. Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Abstract
PURPOSE OF REVIEW: Bone marrow adipocytes (BMAs) have distinct molecular properties and physiologic responses depending on their location within the skeleton. RECENT FINDINGS: This concept was introduced in the 1970s and validated more recently in the contexts of cold exposure, sympathetic tone, hematopoiesis, diabetes, lactation, fasting and caloric restriction. SUMMARY: In this brief review, we discuss the concept of regulated vs constitutive BMAs, explore their evolutionary and microenvironmental origins, define the site-specific molecular features of BMAs, and discuss the translational implications of the dual bone marrow adipose tissue hypothesis.
PURPOSE OF REVIEW: Bone marrow adipocytes (BMAs) have distinct molecular properties and physiologic responses depending on their location within the skeleton. RECENT FINDINGS: This concept was introduced in the 1970s and validated more recently in the contexts of cold exposure, sympathetic tone, hematopoiesis, diabetes, lactation, fasting and caloric restriction. SUMMARY: In this brief review, we discuss the concept of regulated vs constitutive BMAs, explore their evolutionary and microenvironmental origins, define the site-specific molecular features of BMAs, and discuss the translational implications of the dual bone marrow adipose tissue hypothesis.
Entities:
Keywords:
adipose; bone marrow adipocyte; hematopoiesis; marrow fat; yellow marrow
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