Tony Zitek1, Zachary D Skaggs2, Aryan Rahbar3, Jayme Patel3, Memona Khan4. 1. School of Medicine, University of Nevada, Las Vegas, Las Vegas, Nevada; University Medical Center of Southern Nevada, Las Vegas, Nevada; Kendall Regional Medical Center, Miami, Florida. 2. School of Medicine, University of Nevada, Las Vegas, Las Vegas, Nevada. 3. University Medical Center of Southern Nevada, Las Vegas, Nevada. 4. University of Nevada, Las Vegas, Las Vegas, Nevada.
Abstract
BACKGROUND:Serum lactate increases in states of severe sepsis and shock, but its interpretation may be subject to confounders. Lactated Ringer's solution (LR) is used in the resuscitation of septic patients and contains 28 mmol/L of sodium lactate. OBJECTIVES: We sought to determine if a bolus of 30 mL/kg of LR increases serum lactate levels. METHODS: In this double-blind, randomized controlled trial, 30 volunteers were assigned to receive either 30 mL/kg of intravenous LR or normal saline (NS). Serum lactate was measured before and after the fluid bolus. The primary outcome was the difference in the change in lactate between the LR and NS groups. Secondarily, we assessed the change in pH, bicarbonate, sodium, and chloride in each group. RESULTS: After 30 mL/kg of intravenous LR, the mean serum lactate level increased by 0.93 mmol/L (95% confidence interval 0.42-1.44 mmol/L). However, there was also a small increase in the mean serum lactate level in the NS group of 0.37 mmol/L (95% confidence interval -0.26 mmol/L to 1.00 mmol/L), such that there was not a statistically significant difference in the change in lactate when comparing the LR group to the NS group (p = 0.2). The NS group saw larger declines in pH and bicarbonate and greater increases in chloride compared with the LR group. CONCLUSION: In healthy individuals, a modest but significant rise in mean serum lactate was seen after a 30 cc/kg LR bolus. There was no difference in mean serum lactate when comparing a 30 mL/kg bolus of NS to LR.
RCT Entities:
BACKGROUND: Serum lactate increases in states of severe sepsis and shock, but its interpretation may be subject to confounders. Lactated Ringer's solution (LR) is used in the resuscitation of septic patients and contains 28 mmol/L of sodium lactate. OBJECTIVES: We sought to determine if a bolus of 30 mL/kg of LR increases serum lactate levels. METHODS: In this double-blind, randomized controlled trial, 30 volunteers were assigned to receive either 30 mL/kg of intravenous LR or normal saline (NS). Serum lactate was measured before and after the fluid bolus. The primary outcome was the difference in the change in lactate between the LR and NS groups. Secondarily, we assessed the change in pH, bicarbonate, sodium, and chloride in each group. RESULTS: After 30 mL/kg of intravenous LR, the mean serum lactate level increased by 0.93 mmol/L (95% confidence interval 0.42-1.44 mmol/L). However, there was also a small increase in the mean serum lactate level in the NS group of 0.37 mmol/L (95% confidence interval -0.26 mmol/L to 1.00 mmol/L), such that there was not a statistically significant difference in the change in lactate when comparing the LR group to the NS group (p = 0.2). The NS group saw larger declines in pH and bicarbonate and greater increases in chloride compared with the LR group. CONCLUSION: In healthy individuals, a modest but significant rise in mean serum lactate was seen after a 30 cc/kg LR bolus. There was no difference in mean serum lactate when comparing a 30 mL/kg bolus of NS to LR.
Authors: Nikhil Jagan; Lee E Morrow; Ryan W Walters; Robert W Plambeck; Tej M Patel; Douglas R Moore; Mark A Malesker Journal: Ann Intensive Care Date: 2021-02-05 Impact factor: 6.925
Authors: Biswajit Khatua; Jordan R Yaron; Bara El-Kurdi; Sergiy Kostenko; Georgios I Papachristou; Vijay P Singh Journal: J Clin Med Date: 2020-01-18 Impact factor: 4.241