Literature DB >> 30036863

Long-Term Response with Eribulin Mesylate in a Breast Cancer Patient: A Case Report.

Marta Medici, Emanuela Fossile.   

Abstract

Despite the wide pharmacological armamentarium available for the treatment of metastatic breast cancer (MBC), long-lasting control of disease is challenging, especially in heavily pretreated patients. In this case report, we documented a long-lasting complete response (CR) with eribulin in a relatively young woman with MBC and bone metastasis, who did not benefit from prior chemotherapy regimens. Besides CR, the patient was able to maintain an excellent performance status and was free from the severe pain experienced before the initiation of eribulin. Noteworthy, eribulin treatment was very well tolerated, with only a mild alopecia being reported; response was maintained also after a temporary dose interruption and a therapeutic holiday due to non-treatment-related increase in liver enzymes and steatosis.
© 2018 S. Karger AG, Basel.

Entities:  

Keywords:  Bone metastasis; Eribulin ; Long-lasting complete response ; Metastatic breast cancer

Mesh:

Substances:

Year:  2018        PMID: 30036863      PMCID: PMC6193745          DOI: 10.1159/000489061

Source DB:  PubMed          Journal:  Oncology        ISSN: 0030-2414            Impact factor:   2.935


  8 in total

1.  Eribulin induces irreversible mitotic blockade: implications of cell-based pharmacodynamics for in vivo efficacy under intermittent dosing conditions.

Authors:  Murray J Towle; Kathleen A Salvato; Bruce F Wels; Kimberley K Aalfs; Wanjun Zheng; Boris M Seletsky; Xiaojie Zhu; Bryan M Lewis; Yoshito Kishi; Melvin J Yu; Bruce A Littlefield
Journal:  Cancer Res       Date:  2010-12-02       Impact factor: 12.701

2.  Long-term treatment with eribulin in heavily pretreated women with metastatic breast cancer: a case series.

Authors:  Maria Morritti; Giuseppe Iodice; Assunta Melaccio; Loretta D'Onofrio; Paola Bergnolo; Antonella Boglione; Alessandro Comandone; Peppina Molinaro; Danula Garigliano
Journal:  Future Oncol       Date:  2017-04       Impact factor: 3.404

3.  Eribulin long-term response and rechallenge: report of two clinical cases.

Authors:  Elena Barbieri; Daniela Rubino; Rossella Hakim; Angela Fini; Manuela Lenzi; Claudio Zamagni
Journal:  Future Oncol       Date:  2017-04       Impact factor: 3.404

4.  Eribulin monotherapy versus treatment of physician's choice in patients with metastatic breast cancer (EMBRACE): a phase 3 open-label randomised study.

Authors:  Javier Cortes; Joyce O'Shaughnessy; David Loesch; Joanne L Blum; Linda T Vahdat; Katarina Petrakova; Philippe Chollet; Alexey Manikas; Veronique Diéras; Thierry Delozier; Vladimir Vladimirov; Fatima Cardoso; Han Koh; Philippe Bougnoux; Corina E Dutcus; Seth Seegobin; Denis Mir; Nicole Meneses; Jantien Wanders; Chris Twelves
Journal:  Lancet       Date:  2011-03-02       Impact factor: 79.321

5.  Long response to eribulin in breast cancer: a case report.

Authors:  Karen Borgonovo; Fausto Petrelli; Mary Cabiddu; Mara Ghilardi; Andrea Coinu; Silvia Seghezzi; Sandro Barni
Journal:  Future Oncol       Date:  2015       Impact factor: 3.404

6.  Inhibition of centromere dynamics by eribulin (E7389) during mitotic metaphase.

Authors:  Tatiana Okouneva; Olga Azarenko; Leslie Wilson; Bruce A Littlefield; Mary Ann Jordan
Journal:  Mol Cancer Ther       Date:  2008-07       Impact factor: 6.261

7.  Phase III open-label randomized study of eribulin mesylate versus capecitabine in patients with locally advanced or metastatic breast cancer previously treated with an anthracycline and a taxane.

Authors:  Peter A Kaufman; Ahmad Awada; Chris Twelves; Louise Yelle; Edith A Perez; Galina Velikova; Martin S Olivo; Yi He; Corina E Dutcus; Javier Cortes
Journal:  J Clin Oncol       Date:  2015-01-20       Impact factor: 44.544

8.  Subgroup Analyses from a Phase 3, Open-Label, Randomized Study of Eribulin Mesylate Versus Capecitabine in Pretreated Patients with Advanced or Metastatic Breast Cancer.

Authors:  Chris Twelves; Ahmad Awada; Javier Cortes; Louise Yelle; Galina Velikova; Martin S Olivo; James Song; Corina E Dutcus; Peter A Kaufman
Journal:  Breast Cancer (Auckl)       Date:  2016-06-28
  8 in total

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