Literature DB >> 3003664

Na/H exchange at the apical membrane of guinea-pig gallbladder epithelium: properties and inhibition by cyclic AMP.

K U Petersen, F Wehner, J M Winterhager.   

Abstract

The properties and, in particular, the cAMP-sensitivity of apical Na/H exchange in guinea-pig gallbladder epithelium were investigated using gravimetric, pH-stat, and microelectrode techniques. Proton secretion was Na-dependent, inhibited by ouabain and amiloride, and insensitive to changes in apical membrane potential. It was markedly reduced by 8-Br-cAMP and PGE1. PGE1 also attenuated the changes in intracellular Na activity produced by luminal Na removal and restoration. Our results suggest inhibition of Na/H exchange by cAMP. In conjunction with the cAMP-induced rise in apical membrane Cl permeability shown previously, this effect can account for inhibition of NaCl absorption by cAMP.

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Year:  1985        PMID： 3003664     DOI： 10.1007/bf00581791

Source DB:  PubMed          Journal:  Pflugers Arch        ISSN： 0031-6768            Impact factor:   3.657


  21 in total

1.  Sodium/proton antiport in brush-border-membrane vesicles isolated from rat small intestine and kidney.

Authors:  H Murer; U Hopfer; R Kinne
Journal:  Biochem J       Date:  1976-03-15       Impact factor: 3.857

2.  Coupled sodium-chloride influx across the brush border of rabbit ileum.

Authors:  H N Nellans; R A Frizzell; S G Schultz
Journal:  Am J Physiol       Date:  1973-08

3.  Stimulation by HCO3- of Na+ transport in rabbit gallbladder.

Authors:  D Cremaschi; S Hénin; G Meyer
Journal:  J Membr Biol       Date:  1979-05-21       Impact factor: 1.843

4.  Bicarbonate effects, electromotive forces and potassium effluxes in rabbit and guinea-pig gall-bladder.

Authors:  D Cremaschi; G Meyer; C Rossetti
Journal:  J Physiol       Date:  1983-02       Impact factor: 5.182

5.  Asymmetric release of cyclic AMP from guinea-pig and rabbit gallbladder.

Authors:  K U Petersen; H Osswald; K Heintze
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-03       Impact factor: 3.000

6.  Cyclic AMP and intracellular ionic activities in Necturus gallbladder.

Authors:  A Diez de los Rios; N E DeRose; W M Armstrong
Journal:  J Membr Biol       Date:  1981       Impact factor: 1.843

7.  Cl-/HCO3- exchange at the apical membrane of Necturus gallbladder.

Authors:  L Reuss; J L Costantin
Journal:  J Gen Physiol       Date:  1984-06       Impact factor: 4.086

8.  Cyclic AMP-induced chloride permeability in the apical membrane of Necturus gallbladder epithelium.

Authors:  K U Petersen; L Reuss
Journal:  J Gen Physiol       Date:  1983-05       Impact factor: 4.086

9.  Na+-H+ exchange at the apical membrane of Necturus gallbladder. Extracellular and intracellular pH studies.

Authors:  S A Weinman; L Reuss
Journal:  J Gen Physiol       Date:  1982-08       Impact factor: 4.086

10.  Independence of apical membrane Na+ and Cl- entry in Necturus gallbladder epithelium.

Authors:  L Reuss
Journal:  J Gen Physiol       Date:  1984-09       Impact factor: 4.086
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  8 in total

Review 1.  The gallbladder also secretes.

Authors:  D J Glickerman; M H Kim; R Malik; S P Lee
Journal:  Dig Dis Sci       Date:  1997-03       Impact factor: 3.199

2.  Selective blockage of cell membrane K conductance by an antisecretory agent in guinea-pig gallbladder epithelium.

Authors:  F Wehner; J M Winterhager; K U Petersen
Journal:  Pflugers Arch       Date:  1989-07       Impact factor: 3.657

3.  Mechanisms of fluid secretion induced by cAMP and related agents in gallbladder.

Authors:  K U Peterson
Journal:  Dig Dis Sci       Date:  1993-10       Impact factor: 3.199

4.  Inflammatory cytokines alter human gallbladder epithelial cell absorption/secretion.

Authors:  R V Rege
Journal:  J Gastrointest Surg       Date:  2000 Mar-Apr       Impact factor: 3.452

5.  Transcellular bicarbonate transport in rabbit gallbladder epithelium: mechanisms and effects of cyclic AMP.

Authors:  K U Petersen; F Wehner; J M Winterhager
Journal:  Pflugers Arch       Date:  1990-05       Impact factor: 3.657

Review 6.  Cholesterol gallstone disease: focusing on the role of gallbladder.

Authors:  Yongsheng Chen; Jing Kong; Shuodong Wu
Journal:  Lab Invest       Date:  2014-12-15       Impact factor: 5.662

7.  Nature of the neutral Na(+)-Cl- coupled entry at the apical membrane of rabbit gallbladder epithelium: IV. Na+/H+, Cl-/HCO3- double exchange, hydrochlorothiazide-sensitive Na(+)-Cl- symport and Na(+)-K(+)-2Cl- cotransport are all involved.

Authors:  D Cremaschi; C Porta; G Bottà; G Meyer
Journal:  J Membr Biol       Date:  1992-09       Impact factor: 1.843

8.  Electrogenic bicarbonate secretion in gallbladder: induction by barium via neuronal, possibly VIP-ergic pathways.

Authors:  K U Petersen; R Goergen; F Höfken; H J Macherey; G Sprakties
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-11       Impact factor: 3.000
  8 in total

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