Literature DB >> 30036520

The Secretin/Secretin Receptor Axis Modulates Ductular Reaction and Liver Fibrosis through Changes in Transforming Growth Factor-β1-Mediated Biliary Senescence.

Nan Wu1, Fanyin Meng2, Tianhao Zhou1, Julie Venter1, Thao K Giang1, Konstantina Kyritsi1, Chaodong Wu3, Domenico Alvaro4, Paolo Onori5, Romina Mancinelli5, Eugenio Gaudio5, Heather Francis6, Gianfranco Alpini7, Shannon Glaser6, Antonio Franchitto8.   

Abstract

Activation of the secretin (Sct)/secretin receptor (SR) axis stimulates ductular reaction and liver fibrosis, which are hallmarks of cholangiopathies. Our aim was to define the role of Sct-regulated cellular senescence, and we demonstrated that both ductular reaction and liver fibrosis are significantly reduced in Sct-/-, SR-/-, and Sct-/-/SR-/- bile duct ligated (BDL) mice compared with BDL wild-type mice. The reduction in hepatic fibrosis in Sct-/-, SR-/-, and Sct-/-/SR-/- BDL mice was accompanied by reduced transforming growth factor-β1 levels in serum and cholangiocyte supernatant, as well as decreased expression of markers of cellular senescence in cholangiocytes in contrast to enhanced cellular senescence in hepatic stellate cells compared with BDL wild-type mice. Secretin directly stimulated the senescence of cholangiocytes and regulated, by a paracrine mechanism, the senescence of hepatic stellate cells and liver fibrosis via modulation of transforming growth factor-β1 biliary secretion. Targeting senescent cholangiocytes may represent a novel therapeutic approach for ameliorating hepatic fibrosis during cholestatic liver injury.
Copyright © 2018 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

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Year:  2018        PMID： 30036520      PMCID： PMC6168967          DOI： 10.1016/j.ajpath.2018.06.015

Source DB:  PubMed          Journal:  Am J Pathol        ISSN： 0002-9440            Impact factor:   4.307


  49 in total

1.  Inhibition of mast cell-secreted histamine decreases biliary proliferation and fibrosis in primary sclerosing cholangitis Mdr2(-/-) mice.

Authors:  Hannah Jones; Laura Hargrove; Lindsey Kennedy; Fanyin Meng; Allyson Graf-Eaton; Jennifer Owens; Gianfranco Alpini; Christopher Johnson; Francesca Bernuzzi; Jennifer Demieville; Sharon DeMorrow; Pietro Invernizzi; Heather Francis
Journal:  Hepatology       Date:  2016-07-30       Impact factor: 17.425

2.  Forkhead box A2 regulates biliary heterogeneity and senescence during cholestatic liver injury in mice‡.

Authors:  Kelly McDaniel; Fanyin Meng; Nan Wu; Keisaku Sato; Julie Venter; Francesca Bernuzzi; Pietro Invernizzi; Tianhao Zhou; Konstantina Kyritsi; Ying Wan; Qiaobing Huang; Paolo Onori; Heather Francis; Eugenio Gaudio; Shannon Glaser; Gianfranco Alpini
Journal:  Hepatology       Date:  2016-11-05       Impact factor: 17.425

3.  Primary Sclerosing Cholangitis.

Authors:  Konstantinos N Lazaridis; Nicholas F LaRusso
Journal:  N Engl J Med       Date:  2016-12-22       Impact factor: 91.245

4.  Heterogeneity of the proliferative capacity of rat cholangiocytes after bile duct ligation.

Authors:  G Alpini; S S Glaser; Y Ueno; L Pham; P V Podila; A Caligiuri; G LeSage; N F LaRusso
Journal:  Am J Physiol       Date:  1998-04

5.  After damage of large bile ducts by gamma-aminobutyric acid, small ducts replenish the biliary tree by amplification of calcium-dependent signaling and de novo acquisition of large cholangiocyte phenotypes.

Authors:  Romina Mancinelli; Antonio Franchitto; Eugenio Gaudio; Paolo Onori; Shannon Glaser; Heather Francis; Julie Venter; Sharon Demorrow; Guido Carpino; Shelley Kopriva; Mellanie White; Giammarco Fava; Domenico Alvaro; Gianfranco Alpini
Journal:  Am J Pathol       Date:  2010-02-25       Impact factor: 4.307

Review 6.  Recent advances in the morphological and functional heterogeneity of the biliary epithelium.

Authors:  Yuyan Han; Shannon Glaser; Fanyin Meng; Heather Francis; Marco Marzioni; Kelly McDaniel; Domenico Alvaro; Julie Venter; Guido Carpino; Paolo Onori; Eugenio Gaudio; Gianfranco Alpini; Antonio Franchitto
Journal:  Exp Biol Med (Maywood)       Date:  2013-05

7.  Prolonged administration of secretin to normal rats increases biliary proliferation and secretin-induced ductal secretory activity.

Authors:  Micheleine Guerrier; Fabia Attili; Gianfranco Alpini; Shannon Glaser
Journal:  Hepatobiliary Surg Nutr       Date:  2014-06       Impact factor: 7.293

8.  Upregulation of secretin receptor gene expression in rat cholangiocytes after bile duct ligation.

Authors:  G Alpini; C D Ulrich; J O Phillips; L D Pham; L J Miller; N F LaRusso
Journal:  Am J Physiol       Date:  1994-05

9.  Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2.

Authors:  Tian Lan; Changzheng Li; Guizhi Yang; Yue Sun; Lihang Zhuang; Yitao Ou; Hui Li; Genshu Wang; Tatiana Kisseleva; David Brenner; Jiao Guo
Journal:  Hepatology       Date:  2018-04-27       Impact factor: 17.425

10.  The role of the secretin/secretin receptor axis in inflammatory cholangiocyte communication via extracellular vesicles.

Authors:  Keisaku Sato; Fanyin Meng; Julie Venter; Thao Giang; Shannon Glaser; Gianfranco Alpini
Journal:  Sci Rep       Date:  2017-09-11       Impact factor: 4.379
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  17 in total

Review 1.  Cholangiocarcinoma: novel therapeutic targets.

Authors:  Keisaku Sato; Shannon Glaser; Domenico Alvaro; Fanyin Meng; Heather Francis; Gianfranco Alpini
Journal:  Expert Opin Ther Targets       Date:  2020-02-26       Impact factor: 6.902

2.  The Dynamic Interplay Between Mast Cells, Aging/Cellular Senescence, and Liver Disease.

Authors:  Debjyoti Kundu; Lindsey Kennedy; Vik Meadows; Leonardo Baiocchi; Gianfranco Alpini; Heather Francis
Journal:  Gene Expr       Date:  2020-07-29

Review 3.  Preclinical insights into cholangiopathies: disease modeling and emerging therapeutic targets.

Authors:  Keisaku Sato; Shannon Glaser; Lindsey Kennedy; Suthat Liangpunsakul; Fanyin Meng; Heather Francis; Gianfranco Alpini
Journal:  Expert Opin Ther Targets       Date:  2019-04-22       Impact factor: 6.902

4.  Melatonin receptor 1A, but not 1B, knockout decreases biliary damage and liver fibrosis during cholestatic liver injury.

Authors:  Nan Wu; Guido Carpino; Ludovica Ceci; Leonardo Baiocchi; Heather Francis; Lindsey Kennedy; Tianhao Zhou; Lixian Chen; Keisaku Sato; Konstantina Kyritsi; Vik Meadows; Burcin Ekser; Antonio Franchitto; Romina Mancinelli; Paolo Onori; Eugenio Gaudio; Shannon Glaser; Gianfranco Alpini
Journal:  Hepatology       Date:  2021-11-24       Impact factor: 17.425

Review 5.  The Spectrum of Reactive Cholangiocytes in Primary Sclerosing Cholangitis.

Authors:  Maria Eugenia Guicciardi; Christy E Trussoni; Nicholas F LaRusso; Gregory J Gores
Journal:  Hepatology       Date:  2020-02       Impact factor: 17.425

6.  Downregulation of hepatic stem cell factor by Vivo-Morpholino treatment inhibits mast cell migration and decreases biliary damage/senescence and liver fibrosis in Mdr2-/- mice.

Authors:  Vik Meadows; Lindsey Kennedy; Laura Hargrove; Jennifer Demieville; Fanyin Meng; Shohaib Virani; Evan Reinhart; Konstantina Kyritsi; Pietro Invernizzi; Zhihong Yang; Nan Wu; Suthat Liangpunsakul; Gianfranco Alpini; Heather Francis
Journal:  Biochim Biophys Acta Mol Basis Dis       Date:  2019-09-13       Impact factor: 5.187

7.  Inhibition of Secretin/Secretin Receptor Axis Ameliorates NAFLD Phenotypes.

Authors:  Lixian Chen; Nan Wu; Shannon Glaser; Gianfranco Alpini; Lindsey Kennedy; Heather Francis; Ludovica Ceci; Tianhao Zhou; Niharika Samala; Konstantina Kyritsi; Chaodong Wu; Amelia Sybenga; Burcin Ekser; Wasim Dar; Constance Atkins; Vik Meadows
Journal:  Hepatology       Date:  2021-07-29       Impact factor: 17.298

Review 8.  Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies.

Authors:  Keisaku Sato; Fanyin Meng; Heather Francis; Nan Wu; Lixian Chen; Lindsey Kennedy; Tianhao Zhou; Antonio Franchitto; Paolo Onori; Eugenio Gaudio; Shannon Glaser; Gianfranco Alpini
Journal:  J Pineal Res       Date:  2020-03-04       Impact factor: 13.007

Review 9.  Organoids and Spheroids as Models for Studying Cholestatic Liver Injury and Cholangiocarcinoma.

Authors:  Burcin Ekser; Gianfranco Alpini; Keisaku Sato; Wenjun Zhang; Samira Safarikia; Abdulkadir Isidan; Angela M Chen; Ping Li; Heather Francis; Lindsey Kennedy; Leonardo Baiocchi; Domenico Alvaro; Shannon Glaser
Journal:  Hepatology       Date:  2021-06-04       Impact factor: 17.298

10.  Mast Cells Induce Ductular Reaction Mimicking Liver Injury in Mice Through Mast Cell-Derived Transforming Growth Factor Beta 1 Signaling.

Authors:  Konstantina Kyritsi; Lindsey Kennedy; Vik Meadows; Laura Hargrove; Jennifer Demieville; Linh Pham; Amelia Sybenga; Debjyoti Kundu; Karla Cerritos; Fanyin Meng; Gianfranco Alpini; Heather Francis
Journal:  Hepatology       Date:  2021-04-19       Impact factor: 17.298
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