Literature DB >> 3003624

Stimulation of noradrenaline synthesis by the calcium ionophore A23187 and its modulation by presynaptic receptors.

P J Birch, M Fillenz.   

Abstract

Noradrenaline (NA) synthesis in rat hippocampal synaptosomes is increased by calcium ionophore, A23187, in the presence of calcium. Activation of presynaptic muscarinic, gamma-aminobutyric acidB (GABAB) and alpha 2-adrenergic receptors causes inhibition of the ionophore-stimulated synthesis. The results suggest that different mechanisms mediate the depression by presynaptic receptors of NA release and NA synthesis.

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Year:  1985        PMID: 3003624     DOI: 10.1016/0304-3940(85)90353-2

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN: 0304-3940            Impact factor:   3.046


  1 in total

1.  Noradrenaline synthesis after sympathetic nerve activation in rat atria and its dependence on calcium but not CAM kinase II and protein kinases A or C.

Authors:  P Kotsonis; J Binko; H Majewski
Journal:  Br J Pharmacol       Date:  1996-12       Impact factor: 8.739

  1 in total

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