Literature DB >> 30036119

The roles of PPARs in human diseases.

Jingjing Li1, Yi-Ping Liu1.   

Abstract

Peroxisome proliferator-activated receptors (PPARs), as members of nuclear hormone receptor superfamily, can be activated by binding natural or synthetic ligands. The use of related ligands has revealed many potential roles for PPARs in the pathogenesis of some human metabolic disorders and inflammatory-related disease. Based on the previous studies, this review primarily concluded the current progress of knowledge regarding the specific biological activity of PPARs in cancers, atherosclerosis, and type 2 diabetes mellitus, providing a foundation for the potential therapeutic use of PPAR ligands in human diseases.

Entities:  

Keywords:  atherosclerosis; cancers; type 2 diabetes mellitus

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Year:  2018        PMID： 30036119     DOI： 10.1080/15257770.2018.1475673

Source DB:  PubMed          Journal:  Nucleosides Nucleotides Nucleic Acids        ISSN： 1525-7770            Impact factor:   1.381


  3 in total

1.  Bexarotene inhibits cell proliferation by inducing oxidative stress, DNA damage and apoptosis via PPARγ/ NF-κB signaling pathway in C6 glioma cells.

Authors:  Ceyhan Hacioglu; Fatih Kar; Sedat Kacar; Varol Sahinturk; Gungor Kanbak
Journal:  Med Oncol       Date:  2021-02-18       Impact factor: 3.064

2.  Proteome and transcriptome analysis revealed florfenicol via affected drug metabolism and lipid metabolism induce liver injury of broilers.

Authors:  Chao Han; Yuqing Cui; Yiwei Guo; Di Zhang; Xiao Wang; Yumeng Geng; Wanyu Shi; Yongzhan Bao
Journal:  Poult Sci       Date:  2021-05-04       Impact factor: 3.352

Review 3.  Trace Elements, PPARs, and Metabolic Syndrome.

Authors:  Yujie Shi; Yixin Zou; Ziyue Shen; Yonghong Xiong; Wenxiang Zhang; Chang Liu; Siyu Chen
Journal:  Int J Mol Sci       Date:  2020-04-09       Impact factor: 5.923
  3 in total

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