BACKGROUND: Functional mitral valve regurgitation is a frequent consequence of left ventricular dysfunction in patients with severe heart failure and is associated with a poor prognosis. It is hypothesized that in this patient group the mitral valve repair, respectively replacement, improves hemodynamics and clinical symptoms. As operative interventions with the help of heart-lung-machine are high risk procedures in these cases, the transcatheter mitral repair with MitraClip® (Abbott Vascular, IL, USA) has recently become frequently used. Most of these cases experience a progress in left ventricular dysfunction, which finally leads to in an implantation of a left ventricular assist device. In this report, we describe a series of six cases in which patients with end stage heart failure and consecutive functional mitral valve regurgitation were supported with a left ventricular assist device after MitraClip implantation. We aimed to investigate, whether the MitraClip implantation leads to an improvement of the hemodynamic prior left ventricular assist device (LVAD)-implantation. METHODS: We retrospectively analyzed the data of 6 patients (5 males, 1 female) with severe heart failure, who underwent LVAD implantation after the MitraClip procedure. The mean age at MitraClip procedure was 64.6 years, mean age at time of LVAD implantation was 65.5 years. The parameters examined were cardiac index (CI), left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD) and the pulmonary capillary wedge pressure (PCWP). RESULTS: All patients had functional mitral regurgitation (MR). Severity of MR was reduced successfully in all treated patients. All patients were discharged with MR I-II and NYHA functional class III or IV after MitraClip procedure. The mean CI was 2.93 before MitraClip procedure and 2.36 before LVAD-Implantation. Mean LVEDD was 71 mm before MitraClip, mean LVEDD was 70.6 mm before LVAD, and 63.2mm after LVAD implantation respectively. The mean PCWP was 21.5 mmHg before MitraClip and 19.8 mmHg before LVAD implantation respectively. The mean left ventricular ejection fraction (LVEF) was 19.2% before MitraClip, the mean LVEF was 17.6% before LVAD and 15% after LVAD implantation. Two of the LVAD implanted patients died due to post-operative complications. There were no complications after MitraClip procedure. CONCLUSIONS: Our presented patient cohort presented little hemodynamic improvement after the MitraClip procedure. There was no clinical benefit for the patients after MitraClip procedure, progressing left ventricular dysfunction could not be prevented and resulted in subsequent LVAD implantation.
BACKGROUND: Functional mitral valve regurgitation is a frequent consequence of left ventricular dysfunction in patients with severe heart failure and is associated with a poor prognosis. It is hypothesized that in this patient group the mitral valve repair, respectively replacement, improves hemodynamics and clinical symptoms. As operative interventions with the help of heart-lung-machine are high risk procedures in these cases, the transcatheter mitral repair with MitraClip® (Abbott Vascular, IL, USA) has recently become frequently used. Most of these cases experience a progress in left ventricular dysfunction, which finally leads to in an implantation of a left ventricular assist device. In this report, we describe a series of six cases in which patients with end stage heart failure and consecutive functional mitral valve regurgitation were supported with a left ventricular assist device after MitraClip implantation. We aimed to investigate, whether the MitraClip implantation leads to an improvement of the hemodynamic prior left ventricular assist device (LVAD)-implantation. METHODS: We retrospectively analyzed the data of 6 patients (5 males, 1 female) with severe heart failure, who underwent LVAD implantation after the MitraClip procedure. The mean age at MitraClip procedure was 64.6 years, mean age at time of LVAD implantation was 65.5 years. The parameters examined were cardiac index (CI), left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD) and the pulmonary capillary wedge pressure (PCWP). RESULTS: All patients had functional mitral regurgitation (MR). Severity of MR was reduced successfully in all treated patients. All patients were discharged with MR I-II and NYHA functional class III or IV after MitraClip procedure. The mean CI was 2.93 before MitraClip procedure and 2.36 before LVAD-Implantation. Mean LVEDD was 71 mm before MitraClip, mean LVEDD was 70.6 mm before LVAD, and 63.2mm after LVAD implantation respectively. The mean PCWP was 21.5 mmHg before MitraClip and 19.8 mmHg before LVAD implantation respectively. The mean left ventricular ejection fraction (LVEF) was 19.2% before MitraClip, the mean LVEF was 17.6% before LVAD and 15% after LVAD implantation. Two of the LVAD implanted patients died due to post-operative complications. There were no complications after MitraClip procedure. CONCLUSIONS: Our presented patient cohort presented little hemodynamic improvement after the MitraClip procedure. There was no clinical benefit for the patients after MitraClip procedure, progressing left ventricular dysfunction could not be prevented and resulted in subsequent LVAD implantation.
Entities:
Keywords:
Left ventricular assist device (LVAD); MitraClip
Authors: Jan D Schmitto; Lawrence S Lee; Suyog A Mokashi; Ralph M Bolman; Lawrence H Cohn; Frederick Y Chen Journal: Cardiol Rev Date: 2010 Nov-Dec Impact factor: 2.644
Authors: Soon J Park; Carmelo A Milano; Antone J Tatooles; Joseph G Rogers; Robert M Adamson; D Eric Steidley; Gregory A Ewald; Kartik S Sundareswaran; David J Farrar; Mark S Slaughter Journal: Circ Heart Fail Date: 2012-01-26 Impact factor: 8.790
Authors: Jan D Schmitto; Jasmin S Hanke; Sebastian V Rojas; Murat Avsar; Axel Haverich Journal: J Heart Lung Transplant Date: 2015-03-07 Impact factor: 10.247
Authors: Christina Feldmann; Anamika Chatterjee; Jasmin S Hanke; Guenes Dogan; Axel Haverich; Jan D Schmitto Journal: J Thorac Dis Date: 2017-06 Impact factor: 2.895
Authors: Marcel Ricklefs; Jasmin S Hanke; Günes Dogan; L Christian Napp; Christina Feldmann; Axel Haverich; Jan D Schmitto Journal: Semin Thorac Cardiovasc Surg Date: 2018-01-31
Authors: Shuichi Kitada; Tomoko S Kato; Sunu S Thomas; Suzanne D Conwell; Cesare Russo; Marco R Di Tullio; Maryjane Farr; P Christian Schulze; Nir Uriel; Ulrich P Jorde; Hiroo Takayama; Yoshifumi Naka; Shunichi Homma; Donna M Mancini Journal: J Heart Lung Transplant Date: 2013-07-11 Impact factor: 10.247
Authors: James K Kirklin; David C Naftel; Francis D Pagani; Robert L Kormos; Lynne W Stevenson; Elizabeth D Blume; Susan L Myers; Marissa A Miller; J Timothy Baldwin; James B Young Journal: J Heart Lung Transplant Date: 2015-10-08 Impact factor: 10.247
Authors: Henrik Fox; Takayuki Gyoten; Sebastian V Rojas; Marcus-André Deutsch; René Schramm; Volker Rudolph; Jan F Gummert; Michiel Morshuis Journal: J Cardiovasc Transl Res Date: 2021-10-28 Impact factor: 3.216
Authors: Michael M Kreusser; Sonja Hamed; Andreas Weber; Bastian Schmack; Martin J Volz; Nicolas A Geis; Leonie Grossekettler; Sven T Pleger; Arjang Ruhparwar; Hugo A Katus; Philip W Raake Journal: ESC Heart Fail Date: 2020-10-26