Literature DB >> 30033181

Microbes and Alzheimer's Disease: New Findings Call for a Paradigm Change.

Jürgen G Haas1, Richard Lathe2.   

Abstract

Two papers in Neuron provide compelling new indications of a link between herpesviruses and Alzheimer's disease (AD). Readhead et al. report an increased abundance of human herpesviruses 6A and 7 (HHV-6A/7) in AD brain, whereas Eimer et al. show that binding of the AD signature protein, Aβ, to herpes simplex virus type 1 (HSV-1) and HHV-6 surface glycoproteins causes fibrillar Aβ agglutination that can protect against viral challenge.
Copyright © 2018 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  HHV-6; HHV-7; HSV-1; Neurodegeneration; antimicrobial protein; herpesvirus

Mesh：

Year:  2018        PMID： 30033181     DOI： 10.1016/j.tins.2018.07.001

Source DB:  PubMed          Journal:  Trends Neurosci        ISSN： 0166-2236            Impact factor:   13.837


  9 in total

1.  Human Herpesvirus 6 Detection in Alzheimer's Disease Cases and Controls across Multiple Cohorts.

Authors:  Mary Alice Allnutt; Kory Johnson; David A Bennett; Sarah M Connor; Juan C Troncoso; Olga Pletnikova; Marilyn S Albert; Susan M Resnick; Sonja W Scholz; Philip L De Jager; Steven Jacobson
Journal:  Neuron       Date:  2020-01-23       Impact factor: 17.173

Review 2.  Endoplasmic Reticulum Stress and Its Role in Homeostasis and Immunity of Central and Peripheral Neurons.

Authors:  Caroline Perner; Elke Krüger
Journal:  Front Immunol       Date:  2022-04-27       Impact factor: 8.786

Review 3.  The MUC6/AP2A2 Locus and Its Relevance to Alzheimer's Disease: A Review.

Authors:  Peter T Nelson; David W Fardo; Yuriko Katsumata
Journal:  J Neuropathol Exp Neurol       Date:  2020-06-01       Impact factor: 3.685

4.  Herpes Infections and Dementia: Rebutting Alternative Fact.

Authors:  Richard Lathe; Nian-Sheng Tzeng; Ruth Itzhaki
Journal:  Neurotherapeutics       Date:  2019-01       Impact factor: 7.620

Review 5.  "Amyloid-beta accumulation cycle" as a prevention and/or therapy target for Alzheimer's disease.

Authors:  Chinthalapally V Rao; Adam S Asch; Daniel J J Carr; Hiroshi Y Yamada
Journal:  Aging Cell       Date:  2020-01-25       Impact factor: 9.304

6.  Murine roseolovirus does not accelerate amyloid-β pathology and human roseoloviruses are not over-represented in Alzheimer disease brains.

Authors:  Tarin M Bigley; Monica Xiong; Muhammad Ali; Yun Chen; Chao Wang; Javier Remolina Serrano; Abdallah Eteleeb; Oscar Harari; Liping Yang; Swapneel J Patel; Carlos Cruchaga; Wayne M Yokoyama; David M Holtzman
Journal:  Mol Neurodegener       Date:  2022-01-15       Impact factor: 18.879

7.  An epigenome-wide association study of ambient pyrethroid pesticide exposures in California's central valley.

Authors:  Melissa A Furlong; Kimberly C Paul; Qi Yan; Yu-Hsuan Chuang; Myles G Cockburn; Jeff M Bronstein; Steve Horvath; Beate Ritz
Journal:  Int J Hyg Environ Health       Date:  2020-07-14       Impact factor: 7.401

8.  APOE ϵ4 modifies the relationship between infectious burden and poor cognition.

Authors:  Chen Zhao; Kevin Strobino; Yeseon Park Moon; Ying Kuen Cheung; Ralph L Sacco; Yaakov Stern; Mitchell S V Elkind
Journal:  Neurol Genet       Date:  2020-07-07

9.  Plasma Amyloid-β in Relation to Antibodies Against Herpes Simplex Virus, Cytomegalovirus, and Chlamydophila pneumoniae.

Authors:  Karin Lopatko Lindman; Bodil Weidung; Jan Olsson; Maria Josefsson; Anders Johansson; Sture Eriksson; Göran Hallmans; Fredrik Elgh; Hugo Lövheim
Journal:  J Alzheimers Dis Rep       Date:  2021-04-06
  9 in total

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