Literature DB >> 30032745

MMP-Responsive 'Smart' Drug Delivery and Tumor Targeting.

Qing Yao1, Longfa Kou2, Ying Tu3, Lin Zhu4.   

Abstract

Matrix metalloproteinases (MMPs) are major extracellular enzymes involved in cancer initiation, progression, and metastasis. MMPs are widely used as cancer biomarkers and therapeutic targets. Recently, MMPs have been investigated as robust tumor microenvironmental stimuli for 'smart' MMP-responsive drug delivery and tumor targeting and have shown great potential in cancer diagnosis and therapy. In this article, we review the newly emerging MMP-responsive strategies and major MMP-responsive nanomaterials and nanocarriers used for tumor-targeted delivery of drugs and imaging agents at the tissue, cellular, and intracellular levels. We also discuss the challenges and critical considerations in their development and clinical translation.
Copyright © 2018 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Drug delivery; matrix metalloproteinase; nanocarriers; stimuli-responsive; tumor targeting

Mesh：

Substances：

Year:  2018        PMID： 30032745     DOI： 10.1016/j.tips.2018.06.003

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  46 in total

Review 1.  Recent Advancements in Stimuli Responsive Drug Delivery Platforms for Active and Passive Cancer Targeting.

Authors:  Muhammad Abdur Rahim; Nasrullah Jan; Safiullah Khan; Hassan Shah; Asadullah Madni; Arshad Khan; Abdul Jabar; Shahzeb Khan; Abdelbary Elhissi; Zahid Hussain; Heather C Aziz; Muhammad Sohail; Mirazam Khan; Hnin Ei Thu
Journal:  Cancers (Basel)       Date:  2021-02-07       Impact factor: 6.639

2.  Autocatalytic Delivery of Brain Tumor-targeting, Size-shrinkable Nanoparticles for Treatment of Breast Cancer Brain Metastases.

Authors:  Shenqi Zhang; Gang Deng; Fuyao Liu; Bin Peng; Youmei Bao; Fengyi Du; Ann T Chen; Jun Liu; Zeming Chen; Junning Ma; Xiangjun Tang; Qianxue Chen; Jiangbing Zhou
Journal:  Adv Funct Mater       Date:  2020-02-20       Impact factor: 18.808

3.  Tumor-targeted drug delivery and sensitization by MMP2-responsive polymeric micelles.

Authors:  Qing Yao; Yin Liu; Longfa Kou; Ying Tu; Xing Tang; Lin Zhu
Journal:  Nanomedicine       Date:  2019-04-17       Impact factor: 5.307

4.  Wearable Bioelectronics for Chronic Wound Management.

Authors:  Canran Wang; Ehsan Shirzaei Sani; Wei Gao
Journal:  Adv Funct Mater       Date:  2021-12-26       Impact factor: 19.924

5.  Enhancement of anti-tumor activity in melanoma using arginine deiminase fused with 30Kc19α protein.

Authors:  Haein Lee; Geunhwa Park; Seulha Kim; Boram Son; Jinmyoung Joo; Hee Ho Park; Tai Hyun Park
Journal:  Appl Microbiol Biotechnol       Date:  2022-10-13       Impact factor: 5.560

6.  Masking the immunotoxicity of interleukin-12 by fusing it with a domain of its receptor via a tumour-protease-cleavable linker.

Authors:  Aslan Mansurov; Peyman Hosseinchi; Kevin Chang; Abigail L Lauterbach; Laura T Gray; Aaron T Alpar; Erica Budina; Anna J Slezak; Seounghun Kang; Shijie Cao; Ani Solanki; Suzana Gomes; John-Michael Williford; Melody A Swartz; Juan L Mendoza; Jun Ishihara; Jeffrey A Hubbell
Journal:  Nat Biomed Eng       Date:  2022-05-09       Impact factor: 29.234

7.  Alantolactone-loaded chitosan/hyaluronic acid nanoparticles suppress psoriasis by deactivating STAT3 pathway and restricting immune cell recruitment.

Authors:  Ruijie Chen; Yuan-Yuan Zhai; Lining Sun; Zeqing Wang; Xing Xia; Qing Yao; Longfa Kou
Journal:  Asian J Pharm Sci       Date:  2022-02-27       Impact factor: 9.273

8.  Dissecting MMP P10' and P11' subsite sequence preferences, utilizing a positional scanning, combinatorial triple-helical peptide library.

Authors:  Michal Tokmina-Roszyk; Gregg B Fields
Journal:  J Biol Chem       Date:  2018-09-05       Impact factor: 5.157

9.  MT1-MMP activatable fluorogenic probes with enhanced specificity via high-affinity peptide conjugation for tumor imaging.

Authors:  Xiuru Ji; Shuping Xie; Yan Jiao; Xiaojuan Zhang; Duxin Sun; Victor C Yang; Mei Wang; Huining He; Lu Sun
Journal:  Biomater Sci       Date:  2020-03-18       Impact factor: 6.843

Review 10.  Smart Nanoparticles for Chemo-Based Combinational Therapy.

Authors:  Binita Shrestha; Lijun Wang; Eric M Brey; Gabriela Romero Uribe; Liang Tang
Journal:  Pharmaceutics       Date:  2021-06-08       Impact factor: 6.525
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.