| Literature DB >> 30032461 |
Charles Sylvester1,2, Mysore Siddaiah Krishna3, Jaya Sankar Rao2, Adimoolam Chandrasekar2.
Abstract
The subsequent human migrations that dispersed out of Africa, both prehistoric and historic and colonization of India by modern humans is unanimous, and phylogeny of major mitochondrial DNA haplogroups have played a key role in assessing the genetic origin of people of India. To address more such events, complete mitogenomes of 113 Melakudiya tribe of Southern India were sequenced and 46 individuals showed the presence of west Eurasian autochthonous haplogroups HV14 and U7. Phylogenetic analysis revealed two novel subclades HV14a1b and HV14a1b1 and sequences representing haplogroup U7 were included under previously described subclade U7a3a1a2* specific to India. Moreover, the present analysis on complete mtDNA reveals addition information of the spread and distribution of west Eurasian haplogroups in southern India, in tracing an unexplored genetic link between Melakudiya tribe with the people of Iranian Plateau, South Caucasus, and Central Asia. Coalescence ages of HV14 and U7a3a1a2* trees in the present study dates ~ 16.1 ± 4.3 and ~ 13.4 ± 5.6 kya respectively.Entities:
Keywords: Haplogroups; Mitochondrial genome; Neolithic; Phylogenetic; Southern India; Tribe
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Year: 2018 PMID： 30032461 DOI： 10.1007/s10709-018-0030-2
Source DB: PubMed Journal: Genetica ISSN： 0016-6707 Impact factor: 1.082