Literature DB >> 30031972

Identification, structural modification, and dichotomous effects on human immunodeficiency virus type 1 (HIV-1) replication of ingenane esters from Euphorbia kansui.

Qingbo Liu1, Wei Li2, Li Huang3, Yoshihisa Asada4, Susan L Morris-Natschke5, Chin-Ho Chen6, Kuo-Hsiung Lee7, Kazuo Koike8.   

Abstract

Euphorbia kansui showed potent anti-HIV-1 activity during screening of a library composed of plant extracts from Euphorbiaceae and Thymelaeaceae families. Bioassay-guided isolation led to identification of ingenane esters as the active compounds. Further chemical modification resulted in 3-(2-naphthoyl)ingenol (23), which exhibited the most potent anti-HIV-1 activity. Compound 23 also acted as an HIV-1-latency-reversing agent on activation of HIV-1 replication in a latently infected U1 cell model and a T cell latent HIV-1 model JLat-A2.
Copyright © 2018 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  3-(2-Naphthoyl)ingenol; Anti-HIV; Euphorbia kansui; Ingenane; Latency-reversing agent

Mesh：

Substances：

Year:  2018        PMID： 30031972      PMCID： PMC6217806          DOI： 10.1016/j.ejmech.2018.07.020

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  17 in total

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Authors:  Steven J McKerrall; Lars Jørgensen; Christian A Kuttruff; Felix Ungeheuer; Phil S Baran
Journal:  J Am Chem Soc       Date:  2014-04-08       Impact factor: 15.419

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4.  The site of HIV-1 integration in the human genome determines basal transcriptional activity and response to Tat transactivation.

Authors:  A Jordan; P Defechereux; E Verdin
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5.  The first total synthesis of (+/-)-ingenol.

Authors:  Jeffrey D Winkler; Meagan B Rouse; Michael F Greaney; Sean J Harrison; Yoon T Jeon
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6.  Reactivation of HIV-1 from Latency by an Ingenol Derivative from Euphorbia Kansui.

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4.  PKCδ/MAPKs and NF-κB Pathways are Involved in the Regulation of Ingenane-Type Diterpenoids from Euphorbia neriifolia on Macrophage Function.

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5.  Toxicity Reduction of Euphorbia kansui Stir-Fried with Vinegar Based on Conversion of 3-O-(2'E,4'Z-Decadi-enoyl)-20-O-acetylingenol.

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