Maria Cristina Ribeiro Dos Santos Simões1, Yuri Inoue2, Natasha Y Matsunaga3, Maria R V Carvalho4, Gisleine L T Ribeiro4, Eliane O Morais4, Maria A G O Ribeiro3, André M Morcillo5, José D Ribeiro5, Adyléia A D C Toro5. 1. Universidade Estadual de Campinas (Unicamp), Faculdade de Ciências Médicas (FCM), Programa de Pós-Graduação em Saúde da Criança e do Adolescente, Campinas, SP, Brazil; Universidade Estadual de Campinas (Unicamp), Faculdade de Ciências Médicas (FCM), Departamento de Pediatria, Campinas, SP, Brazil. Electronic address: mcris.simoes@gmail.com. 2. Universidade Estadual de Campinas (Unicamp), Faculdade de Ciências Médicas (FCM), Graduação em Medicina, Campinas, SP, Brazil. 3. Universidade Estadual de Campinas (Unicamp), Faculdade de Ciências Médicas (FCM), Programa de Pós-Graduação em Saúde da Criança e do Adolescente, Campinas, SP, Brazil. 4. Universidade Estadual de Campinas (Unicamp), Hospital de Clínicas (HC), Centro de Referência em Imunobiológicos Especiais, Campinas, SP, Brazil. 5. Universidade Estadual de Campinas (Unicamp), Faculdade de Ciências Médicas (FCM), Departamento de Pediatria, Campinas, SP, Brazil.
Abstract
OBJECTIVE: To evaluate the prevalence and risk factors associated with progression to recurrent wheezing in preterm infants. METHODS: The cross-sectional study was carried out in 2014 and 2015 and analyzed preterm infants born between 2011 and 2012. The search for these children was performed in a university maternity hospital and a Special Immunobiological Reference Center. The evaluation was performed through a questionnaire applied during a telephone interview. RESULTS: The study included 445 children aged 39 (18-54) months. In the univariate analysis, the risk factors with the greatest chance of recurrent wheezing were birth weight <1000g, gestational age <28 weeks, living with two or more siblings, food allergy, and atopic dermatitis in the child, as well as food allergy and asthma in the parents. In the multivariate analysis, there was a significant association between recurrent wheezing and gestational age at birth <28 weeks, food allergy and atopic dermatitis in the child, and living with two or more children. Of the 445 analyzed subjects, 194 received passive immunization against the respiratory syncytial virus, and 251 preterm infants were not immunized. There was a difference between the gestational age of these subgroups (p<0.001). The overall prevalence of recurrent wheezing was 27.4% (95% CI: 23.42-31.70), whereas in the children who received passive immunization it was 36.1% (95% CI: 29.55-43.03). CONCLUSIONS: Personal history of atopy, lower gestational age, and living with two or more children had a significant association with recurrent wheezing. Children with lower gestational age who received passive immunization against the respiratory syncytial virus had a higher prevalence of recurrent wheezing than the group with higher gestational age.
OBJECTIVE: To evaluate the prevalence and risk factors associated with progression to recurrent wheezing in preterm infants. METHODS: The cross-sectional study was carried out in 2014 and 2015 and analyzed preterm infants born between 2011 and 2012. The search for these children was performed in a university maternity hospital and a Special Immunobiological Reference Center. The evaluation was performed through a questionnaire applied during a telephone interview. RESULTS: The study included 445 children aged 39 (18-54) months. In the univariate analysis, the risk factors with the greatest chance of recurrent wheezing were birth weight <1000g, gestational age <28 weeks, living with two or more siblings, food allergy, and atopic dermatitis in the child, as well as food allergy and asthma in the parents. In the multivariate analysis, there was a significant association between recurrent wheezing and gestational age at birth <28 weeks, food allergy and atopic dermatitis in the child, and living with two or more children. Of the 445 analyzed subjects, 194 received passive immunization against the respiratory syncytial virus, and 251 preterm infants were not immunized. There was a difference between the gestational age of these subgroups (p<0.001). The overall prevalence of recurrent wheezing was 27.4% (95% CI: 23.42-31.70), whereas in the children who received passive immunization it was 36.1% (95% CI: 29.55-43.03). CONCLUSIONS: Personal history of atopy, lower gestational age, and living with two or more children had a significant association with recurrent wheezing. Children with lower gestational age who received passive immunization against the respiratory syncytial virus had a higher prevalence of recurrent wheezing than the group with higher gestational age.
Authors: Steven M Brunwasser; Brittney M Snyder; Amanda J Driscoll; Deshayne B Fell; David A Savitz; Daniel R Feikin; Becky Skidmore; Niranjan Bhat; Louis J Bont; William D Dupont; Pingsheng Wu; Tebeb Gebretsadik; Patrick G Holt; Heather J Zar; Justin R Ortiz; Tina V Hartert Journal: Lancet Respir Med Date: 2020-08 Impact factor: 30.700