Wenjia Guo1, Tingting Lv2, Fei She3, Guobin Miao3, Yuanwei Liu3, Rong He3, Yajun Xue3, Nang Kham Nu1, Jing Yang3, Kun Li1, Ping Zhang4. 1. School of Clinical Medicine, Tsinghua University, NO.1, Tsinghua Yuan, Haidian District, Beijing, 100084, China. 2. School of Medicine, Tsinghua University, NO.1, Tsinghua Yuan, Haidian District, Beijing, 100084, China. 3. Department of Cardiology, Beijing Tsinghua Changgung Hospital, Tsinghua University, NO.168, LiTang Road, Beijing, 102218, China. 4. School of Clinical Medicine, Tsinghua University, NO.1, Tsinghua Yuan, Haidian District, Beijing, 100084, China; Department of Cardiology, Beijing Tsinghua Changgung Hospital, Tsinghua University, NO.168, LiTang Road, Beijing, 102218, China. Electronic address: zhpdoc@126.com.
Abstract
BACKGROUND: Heart rate variability (HRV), modulated by cardiac autonomic function, is impaired in obstructive sleep apnea (OSA). However, the effect of continuous positive airway pressure (CPAP) on HRV is debated. OBJECTIVES: To investigate the associations between CPAP and HRV in OSA. METHODS: Based on literature from five databases published through August 2017, we performed a meta-analysis of cohort studies of OSA treated with CPAP. The change of low-frequency band (LF), high-frequency band (HF) and the ratio between LF and HF (LHR) were analyzed. RESULTS: Eleven studies were included. Decreased LF (SMD = -0.32, 95%CI: -0.62,-0.01; P = 0.043) and HF (SMD = -0.51, 95%CI: -0.95, -0.08, P = 0.020) were shown while measured on CPAP. When measured off CPAP, HF was increased remarkably (SMD: 0.31, 95%CI: 0.02, 0.60, P = 0.034). CONCLUSIONS: CPAP can improve autonomic activity, which might be one mechanism to reduce the risk of cardiovascular diseases in OSA.
BACKGROUND: Heart rate variability (HRV), modulated by cardiac autonomic function, is impaired in obstructive sleep apnea (OSA). However, the effect of continuous positive airway pressure (CPAP) on HRV is debated. OBJECTIVES: To investigate the associations between CPAP and HRV in OSA. METHODS: Based on literature from five databases published through August 2017, we performed a meta-analysis of cohort studies of OSA treated with CPAP. The change of low-frequency band (LF), high-frequency band (HF) and the ratio between LF and HF (LHR) were analyzed. RESULTS: Eleven studies were included. Decreased LF (SMD = -0.32, 95%CI: -0.62,-0.01; P = 0.043) and HF (SMD = -0.51, 95%CI: -0.95, -0.08, P = 0.020) were shown while measured on CPAP. When measured off CPAP, HF was increased remarkably (SMD: 0.31, 95%CI: 0.02, 0.60, P = 0.034). CONCLUSIONS: CPAP can improve autonomic activity, which might be one mechanism to reduce the risk of cardiovascular diseases in OSA.
Authors: W M Faizal; N N N Ghazali; C Y Khor; Irfan Anjum Badruddin; M Z Zainon; Aznijar Ahmad Yazid; Norliza Binti Ibrahim; Roziana Mohd Razi Journal: Comput Methods Programs Biomed Date: 2020-06-26 Impact factor: 5.428