Literature DB >> 30029960

Conservative management of cervical cancer: Current status and obstetrical implications.

Joël Fokom Domgue1, Kathleen M Schmeler2.   

Abstract

Recent advances in screening and early diagnosis have decreased cervical cancer incidence and mortality rates in high-resource settings. The postponement of childbearing, combined with an increased number of cervical cancer survivors, has yielded new paradigms in patient care. In recent years, radical surgery has been challenged as the standard of care for early-stage cervical cancer owing to its significant morbidity and fertility impairment. Attention has been directed to assessing more conservative procedures that can reduce treatment-induced morbidity without compromising oncologic safety and reproductive potential of patients with early-stage disease. In those with more advanced disease, neoadjuvant chemotherapy followed by conservative surgery has also been considered. These conservative treatment modalities including cervical conization, simple trachelectomy, and simple hysterectomy have been studied in various settings. In this chapter, we discuss the role of conservative surgery in the management of cervical cancer and the resulting obstetrical outcomes.
Copyright © 2018. Published by Elsevier Ltd.

Entities:  

Keywords:  Cervical cancer; Conization; Conservative surgery; Fertility-sparing surgery; Simple hysterectomy; Simple trachelectomy

Mesh:

Year:  2018        PMID: 30029960     DOI: 10.1016/j.bpobgyn.2018.06.009

Source DB:  PubMed          Journal:  Best Pract Res Clin Obstet Gynaecol        ISSN: 1521-6934            Impact factor:   5.237


  5 in total

Review 1.  Fertility preservation techniques in cervical carcinoma.

Authors:  Erica Silvestris; Angelo Virgilio Paradiso; Carla Minoia; Antonella Daniele; Gennaro Cormio; Raffaele Tinelli; Stella D'Oronzo; Paola Cafforio; Vera Loizzi; Miriam Dellino
Journal:  Medicine (Baltimore)       Date:  2022-04-29       Impact factor: 1.817

2.  LINC00511 is associated with the malignant status and promotes cell proliferation and motility in cervical cancer.

Authors:  Chun-Ling Yu; Xiao-Ling Xu; Fang Yuan
Journal:  Biosci Rep       Date:  2019-09-13       Impact factor: 3.840

3.  Fertility-sparing surgery for women with stage I cervical cancer of 4 cm or larger: a systematic review.

Authors:  Violante Di Donato; Giuseppe Caruso; Carolina Maria Sassu; Giusi Santangelo; Giorgio Bogani; Francesco Plotti; Flavia Sorbi; Giorgia Perniola; Innocenza Palaia; Gianluca Terrin; Roberto Angioli; Pierluigi Benedetti Panici; Ludovico Muzii
Journal:  J Gynecol Oncol       Date:  2021-08-04       Impact factor: 4.401

4.  MicroRNA-22 enhances radiosensitivity in cervical cancer cell lines via direct inhibition of c-Myc binding protein, and the subsequent reduction in hTERT expression.

Authors:  Mayumi Nakamura; Masami Hayashi; Hiromi Konishi; Misa Nunode; Keisuke Ashihara; Hiroshi Sasaki; Yoshito Terai; Masahide Ohmichi
Journal:  Oncol Lett       Date:  2020-01-23       Impact factor: 2.967

5.  Outcome and Subsequent Pregnancy after Fertility-Sparing Surgery of Early-Stage Cervical Cancers.

Authors:  Chia-Yi Lee; Yu-Li Chen; Ying-Cheng Chiang; Ching-Yu Cheng; Yen-Ling Lai; Yi-Jou Tai; Heng-Cheng Hsu; Hsiao-Lin Hwa; Wen-Fang Cheng
Journal:  Int J Environ Res Public Health       Date:  2020-09-28       Impact factor: 3.390

  5 in total

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