Literature DB >> 3002988

Computer-controlled large scale production of high specific activity [11C]RO 15-1788 for PET studies of benzodiazepine receptors.

K Suzuki, O Inoue, K Hashimoto, T Yamasaki, M Kuchiki, K Tamate.   

Abstract

Ethyl 8-fluoro-5,6-dihydro-5-[11C]methyl-6-oxo-4H-imidazo [1,5-a] [1,4]benzodiazepine-3-carboxylate ([11C]RO 15-1788) has been prepared automatically with high specific activity for in vivo visualization or quantitative analysis of brain benzodiazepine receptors. The yield, radiochemical yield, radiochemical purity and specific activity of the product ready for an i.v. injection were 276 +/- 76 mCi, 50.8 +/- 7.8%, 99.3 +/- 0.3% and 2.9 +/- 0.5 Ci/mumol, respectively, taking an average of the latest 3 runs. The time required was about 25 min. Each product was sufficient to carry out three successive clinical studies by positron emission tomography (PET). All the procedures other than evaporation and filtration at the final stage were carried out with specially designed equipment connected to a central control system for radioisotope production.

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Year:  1985        PMID： 3002988     DOI： 10.1016/0020-708x(85)90258-3

Source DB:  PubMed          Journal:  Int J Appl Radiat Isot        ISSN： 0020-708X


  12 in total

1.  [11C]Ro 15-4513, a ligand for visualization of benzodiazepine receptor binding. Preparation, autoradiography and positron emission tomography.

Authors:  C Halldin; L Farde; J E Litton; H Hall; G Sedvall
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

2.  In vivo evaluation of limiting brain penetration of probes for α(2C)-adrenoceptor using small-animal positron emission tomography.

Authors:  Kazunori Kawamura; Megumi Akiyama; Joji Yui; Tomoteru Yamasaki; Akiko Hatori; Katsushi Kumata; Hidekatsu Wakizaka; Makoto Takei; Nobuki Nengaki; Kazuhiko Yanamoto; Toshimitsu Fukumura; Ming-Rong Zhang
Journal:  ACS Chem Neurosci       Date:  2010-06-02       Impact factor: 4.418

3.  Age-related changes in human D1 dopamine receptors measured by positron emission tomography.

Authors:  T Suhara; H Fukuda; O Inoue; T Itoh; K Suzuki; T Yamasaki; Y Tateno
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

4.  Synthesis and evaluation of 11C-PK 11195 for in vivo study of peripheral-type benzodiazepine receptors using positron emission tomography.

Authors:  K Hashimoto; O Inoue; K Suzuki; T Yamasaki; M Kojima
Journal:  Ann Nucl Med       Date:  1989-07       Impact factor: 2.668

5.  Evaluation of limiting brain penetration related to P-glycoprotein and breast cancer resistance protein using [(11)C]GF120918 by PET in mice.

Authors:  Kazunori Kawamura; Tomoteru Yamasaki; Fujiko Konno; Joji Yui; Akiko Hatori; Kazuhiko Yanamoto; Hidekatsu Wakizaka; Makoto Takei; Yuichi Kimura; Toshimitsu Fukumura; Ming-Rong Zhang
Journal:  Mol Imaging Biol       Date:  2011-02       Impact factor: 3.488

6.  A ¹¹C-labeled 1,4-dihydroquinoline derivative as a potential PET tracer for imaging of redox status in mouse brain.

Authors:  Toshimitsu Okamura; Maki Okada; Tatsuya Kikuchi; Hidekatsu Wakizaka; Ming-Rong Zhang
Journal:  J Cereb Blood Flow Metab       Date:  2015-06-17       Impact factor: 6.200

7.  Detection of benzodiazepine receptor occupancy in the human brain by positron emission tomography.

Authors:  H Shinotoh; M Iyo; T Yamada; O Inoue; K Suzuki; T Itoh; H Fukuda; T Yamasaki; Y Tateno; K Hirayama
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

8.  [11C]Gefitinib ([11c]Iressa): radiosynthesis, in vitro uptake, and in vivo imaging of intact murine fibrosarcoma.

Authors:  Ming-Rong Zhang; Katsushi Kumata; Akiko Hatori; Nobuhiko Takai; Jun Toyohara; Tomoteru Yamasaki; Kazuhiko Yanamoto; Joji Yui; Kazunori Kawamura; Sachiko Koike; Koichi Ando; Kazutoshi Suzuki
Journal:  Mol Imaging Biol       Date:  2009-09-26       Impact factor: 3.488

9.  Dopamine D1 receptors in Parkinson's disease and striatonigral degeneration: a positron emission tomography study.

Authors:  H Shinotoh; O Inoue; K Hirayama; A Aotsuka; M Asahina; T Suhara; T Yamazaki; Y Tateno
Journal:  J Neurol Neurosurg Psychiatry       Date:  1993-05       Impact factor: 10.154

10.  Improved Visualization and Specific Binding for Metabotropic Glutamate Receptor Subtype 1 (mGluR1) Using [11C]ITMM with Ultra-High Specific Activity in Small-Animal PET.

Authors:  Tomoteru Yamasaki; Masayuki Fujinaga; Joji Yui; Hidekatsu Wakizaka; Tomoyuki Ohya; Nobuki Nengaki; Masanao Ogawa; Yoko Ikoma; Akiko Hatori; Lin Xie; Kazunori Kawamura; Ming-Rong Zhang
Journal:  PLoS One       Date:  2015-06-15       Impact factor: 3.240
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