Yong Woo Kim1,2, Ki Ho Park2. 1. Department of Ophthalmology, Armed Forces Capital Hospital, Seongnam, Korea. 2. Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Abstract
Purpose: To compare the diagnostic accuracy of three-dimensional neuroretinal rim (3D-NRR) and peripapillary retinal nerve fiber layer (RNFL) thickness for differentiation of myopic glaucoma from myopia. Methods: Healthy myopic individuals (n = 193 eyes) and age-matched myopic glaucoma patients (n = 61 eyes) were enrolled. A 200 × 200-optic disc cube scan was performed with Cirrus HD-OCT. The rates of false-positive errors were compared between RNFL and 3D-NRR thickness measurements. The diagnostic accuracies of RNFL and 3D-NRR thickness for myopic glaucoma were compared by calculating the areas under receiver operating characteristic (AUROC) curves and the partial area under the curve (pAUC) for sensitivity ≥90%. Results: The overall false-positive rate was significantly greater for RNFL thickness (26.9%) than for 3D-NRR thickness (2.1%, P < 0.001). False-positive RNFL-thickness errors were prevalent in the nasal peripapillary region. The 3D-NRR thickness relative to RNFL revealed a greater AUROC from the 12 to 6 o'clock and 9 o'clock sectors. Again, comparing 3D-NRR with RNFL thickness, the pAUC for sensitivity ≥90% was greater in the nasal quadrant, 12, 3, 4, and 5 o'clock sectors. Also, the sensitivity and specificity, based on the internal normative database, were greater for 3D-NRR than for RNFL thickness. Conclusions: 3D-NRR thickness measurement reduced the false-positive rate for glaucoma diagnosis and demonstrated better accuracy for glaucoma detection in myopic eyes. Measurement of 3D-NRR can be complementary to RNFL thickness measurement for differentiation of myopic glaucoma from myopia.
Purpose: To compare the diagnostic accuracy of three-dimensional neuroretinal rim (3D-NRR) and peripapillary retinal nerve fiber layer (RNFL) thickness for differentiation of myopic glaucoma from myopia. Methods: Healthy myopic individuals (n = 193 eyes) and age-matched myopic glaucomapatients (n = 61 eyes) were enrolled. A 200 × 200-optic disc cube scan was performed with Cirrus HD-OCT. The rates of false-positive errors were compared between RNFL and 3D-NRR thickness measurements. The diagnostic accuracies of RNFL and 3D-NRR thickness for myopic glaucoma were compared by calculating the areas under receiver operating characteristic (AUROC) curves and the partial area under the curve (pAUC) for sensitivity ≥90%. Results: The overall false-positive rate was significantly greater for RNFL thickness (26.9%) than for 3D-NRR thickness (2.1%, P < 0.001). False-positive RNFL-thickness errors were prevalent in the nasal peripapillary region. The 3D-NRR thickness relative to RNFL revealed a greater AUROC from the 12 to 6 o'clock and 9 o'clock sectors. Again, comparing 3D-NRR with RNFL thickness, the pAUC for sensitivity ≥90% was greater in the nasal quadrant, 12, 3, 4, and 5 o'clock sectors. Also, the sensitivity and specificity, based on the internal normative database, were greater for 3D-NRR than for RNFL thickness. Conclusions: 3D-NRR thickness measurement reduced the false-positive rate for glaucoma diagnosis and demonstrated better accuracy for glaucoma detection in myopic eyes. Measurement of 3D-NRR can be complementary to RNFL thickness measurement for differentiation of myopic glaucoma from myopia.
Authors: Jasmin Rezapour; Christopher Bowd; Jade Dohleman; Akram Belghith; James A Proudfoot; Mark Christopher; Leslie Hyman; Jost B Jonas; Massimo A Fazio; Robert N Weinreb; Linda M Zangwill Journal: Sci Rep Date: 2021-04-23 Impact factor: 4.996