Literature DB >> 3002813

Evidence for GABAB autoreceptors in median eminence.

R A Anderson, R Mitchell.   

Abstract

The effect of the selective GABAB receptor agonist baclofen was examined on stimulus-induced release of [3H]GABA from crude synaptosomal preparations of median eminence (ME) and pituitary neurointermediate lobe (NI). Baclofen stereospecifically inhibited release of [3H]GABA in a concentration-dependent manner from ME but had no effect in NI. The effect of (+/-) baclofen was partly antagonized by the putative GABAB receptor antagonist delta-aminovaleric acid, but these experiments were complicated by a degree of heteroexchange. These results provide the first evidence for GABAB autoreceptors in the CNS.

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Year:  1985        PMID： 3002813     DOI： 10.1016/0014-2999(85)90148-7

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  8 in total

1.  Modeling Starburst cells' GABA(B) receptors and their putative role in motion sensitivity.

Authors:  Norberto M Grzywacz; Charles L Zucker
Journal:  Biophys J       Date:  2006-04-28       Impact factor: 4.033

2.  Release-regulating autoreceptors of the GABAB-type in human cerebral cortex.

Authors:  G Bonanno; P Cavazzani; G C Andrioli; D Asaro; G Pellegrini; M Raiteri
Journal:  Br J Pharmacol       Date:  1989-02       Impact factor: 8.739

3.  Investigations on GABAB receptor-mediated autoinhibition of GABA release.

Authors:  P A Baumann; P Wicki; C Stierlin; P C Waldmeier
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990 Jan-Feb       Impact factor: 3.000

4.  Baclofen and phaclofen modulate GABA release from slices of rat cerebral cortex and spinal cord but not from retina.

Authors:  M J Neal; M A Shah
Journal:  Br J Pharmacol       Date:  1989-09       Impact factor: 8.739

5.  Compartmental localization of gamma-aminobutyric acid type B receptors in the cholinergic circuitry of the rabbit retina.

Authors:  Charles L Zucker; James E Nilson; Berndt Ehinger; Norberto M Grzywacz
Journal:  J Comp Neurol       Date:  2005-12-19       Impact factor: 3.215

6.  A novel type of GABA receptor in rat spinal cord?

Authors:  M Raiteri; G Pellegrini; C Cantoni; G Bonanno
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-12       Impact factor: 3.000

7.  GABA, glutamate and substance P-like immunoreactivity release: effects of novel GABAB antagonists.

Authors:  H Teoh; M Malcangio; N G Bowery
Journal:  Br J Pharmacol       Date:  1996-07       Impact factor: 8.739

8.  Evidence that gamma-aminobutyric acid is part of the neural circuit mediating estradiol negative feedback in anestrous ewes.

Authors:  Adrienne L Bogusz; Steven L Hardy; Michael N Lehman; John M Connors; Stanley M Hileman; Joanna H Sliwowska; Heather J Billings; Christina J McManus; Miroslav Valent; Sushma R Singh; Casey C Nestor; Lique M Coolen; Robert L Goodman
Journal:  Endocrinology       Date:  2008-03-06       Impact factor: 4.736
  8 in total

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