C M Nagle1,2, T Ibiebele3, N Shivappa4,5,6, J R Hébert4,5,6, A DeFazio7,8, P M Webb3,9. 1. Gynaecological Cancers Group, QIMR Berghofer Medical Research Institute, Locked Bag 2000, Royal Brisbane Hospital, Herston, QLD, 4029, Australia. christina.nagle@qimrberghofer.edu.au. 2. Faculty of Medicine, School of Public Health, The University of Queensland, Brisbane, Australia. christina.nagle@qimrberghofer.edu.au. 3. Gynaecological Cancers Group, QIMR Berghofer Medical Research Institute, Locked Bag 2000, Royal Brisbane Hospital, Herston, QLD, 4029, Australia. 4. Cancer Prevention and Control Program, University of South Carolina, 915 Greene Street, Suite 241-2, Columbia, SC, 29208, USA. 5. Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, 915 Greene Street, Suite 400, Columbia, SC, 29208, USA. 6. Connecting Health Innovations LLC (CHI), 1417 Gregg Street, Columbia, SC, 29201, USA. 7. Centre for Cancer Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, Australia. 8. Department of Gynaecological Oncology, Westmead Hospital, Sydney, Australia. 9. Faculty of Medicine, School of Public Health, The University of Queensland, Brisbane, Australia.
Abstract
PURPOSE: Inflammation has been implicated in ovarian carcinogenesis. This study evaluated two dietary indices: the Dietary Inflammatory Index (DII®) and the Empirical Dietary Inflammatory Pattern (EDIP), in relation to risk of developing, and survival following, a diagnosis of ovarian cancer. METHODS: Data came from the Australian Ovarian Cancer Study (1375 cases, 1415 population controls). DII and EDIP scores were computed from dietary information obtained using a semiquantitative food-frequency questionnaire. Logistic regression was used to assess the association between DII and EDIP scores and risk of ovarian cancer and proportional hazards models were used for survival analysis. RESULTS: A high DII score, reflecting a more pro-inflammatory diet, was associated with a modest increased risk of ovarian cancer [odds ratio (OR) DII scoreQ4 vs.Q1 = 1.31, 95% CI 1.06-1.63, ptrend = 0.014]. Likewise a high EDIP score was associated with an increase in risk of ovarian cancer [OR EDIP scoreQ4 vs.Q1 = 1.39, 95% confidence interval (CI) 1.12-1.73, ptrend = 0.002]. We found no association between DII or EDIP score and overall or ovarian cancer-specific survival. CONCLUSION: In conclusion, our results suggest that a pro-inflammatory diet modestly increases the risk of developing ovarian cancer.
PURPOSE: Inflammation has been implicated in ovarian carcinogenesis. This study evaluated two dietary indices: the Dietary Inflammatory Index (DII®) and the Empirical Dietary Inflammatory Pattern (EDIP), in relation to risk of developing, and survival following, a diagnosis of ovarian cancer. METHODS: Data came from the Australian Ovarian Cancer Study (1375 cases, 1415 population controls). DII and EDIP scores were computed from dietary information obtained using a semiquantitative food-frequency questionnaire. Logistic regression was used to assess the association between DII and EDIP scores and risk of ovarian cancer and proportional hazards models were used for survival analysis. RESULTS: A high DII score, reflecting a more pro-inflammatory diet, was associated with a modest increased risk of ovarian cancer [odds ratio (OR) DII scoreQ4 vs.Q1 = 1.31, 95% CI 1.06-1.63, ptrend = 0.014]. Likewise a high EDIP score was associated with an increase in risk of ovarian cancer [OR EDIP scoreQ4 vs.Q1 = 1.39, 95% confidence interval (CI) 1.12-1.73, ptrend = 0.002]. We found no association between DII or EDIP score and overall or ovarian cancer-specific survival. CONCLUSION: In conclusion, our results suggest that a pro-inflammatory diet modestly increases the risk of developing ovarian cancer.
Authors: Lauren C Peres; James R Hebert; Bo Qin; Kristin A Guertin; Elisa V Bandera; Nitin Shivappa; Tareq F Camacho; Deanna Chyn; Anthony J Alberg; Jill S Barnholtz-Sloan; Melissa L Bondy; Michele L Cote; Ellen Funkhouser; Patricia G Moorman; Edward S Peters; Ann G Schwartz; Paul D Terry; Joellen M Schildkraut Journal: J Nutr Date: 2019-09-01 Impact factor: 4.798
Authors: Naoko Sasamoto; Tianyi Wang; Mary K Townsend; A Heather Eliassen; Fred K Tabung; Edward L Giovannucci; Ursula A Matulonis; Kathryn L Terry; Shelley S Tworoger; Holly R Harris Journal: Br J Cancer Date: 2022-06-27 Impact factor: 9.075
Authors: Catherine M Phillips; Ling-Wei Chen; Barbara Heude; Jonathan Y Bernard; Nicholas C Harvey; Liesbeth Duijts; Sara M Mensink-Bout; Kinga Polanska; Giulia Mancano; Matthew Suderman; Nitin Shivappa; James R Hébert Journal: Nutrients Date: 2019-08-12 Impact factor: 5.717
Authors: Kathy Vagianos; Leigh Anne Shafer; Kelcie Witges; Laura E Targownik; Clove Haviva; Lesley A Graff; Kathryn A Sexton; Lisa M Lix; Michael Sargent; Charles N Bernstein Journal: Inflamm Bowel Dis Date: 2021-01-19 Impact factor: 5.325