Literature DB >> 30026371

Mitochondrial abnormalities in Parkinson's disease and Alzheimer's disease: can mitochondria be targeted therapeutically?

Ruby Macdonald1, Katy Barnes1, Christopher Hastings1, Heather Mortiboys2.   

Abstract

Mitochondrial abnormalities have been identified as a central mechanism in multiple neurodegenerative diseases and, therefore, the mitochondria have been explored as a therapeutic target. This review will focus on the evidence for mitochondrial abnormalities in the two most common neurodegenerative diseases, Parkinson's disease and Alzheimer's disease. In addition, we discuss the main strategies which have been explored in these diseases to target the mitochondria for therapeutic purposes, focusing on mitochondrially targeted antioxidants, peptides, modulators of mitochondrial dynamics and phenotypic screening outcomes.
© 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.

Entities:  

Keywords:  Alzheimer's disease; Parkinson's disease; mitochondrial dysfunction; therapeutics

Mesh：

Substances：

Year:  2018        PMID： 30026371     DOI： 10.1042/BST20170501

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  33 in total

Review 1.  Dopamine D3 receptor: A neglected participant in Parkinson Disease pathogenesis and treatment?

Authors:  Pengfei Yang; Joel S Perlmutter; Tammie L S Benzinger; John C Morris; Jinbin Xu
Journal:  Ageing Res Rev       Date:  2019-11-22       Impact factor: 10.895

2.  Thioredoxin-Interacting Protein (TXNIP) Regulates Parkin/PINK1-mediated Mitophagy in Dopaminergic Neurons Under High-glucose Conditions: Implications for Molecular Links Between Parkinson's Disease and Diabetes.

Authors:  Cun-Jin Su; Zhu Shen; Ru-Xiao Cui; Ya Huang; De-Lai Xu; Feng-Lun Zhao; Jie Pan; Ai-Ming Shi; Tong Liu; Yun-Li Yu
Journal:  Neurosci Bull       Date:  2020-01-14       Impact factor: 5.203

Review 3.  A focus on natural products for preventing and cure of mitochondrial dysfunction in Parkinson's disease.

Authors:  Abbas Mohammadipour
Journal:  Metab Brain Dis       Date:  2022-02-14       Impact factor: 3.584

Review 4.  Neurogenetic disorders across the lifespan: from aberrant development to degeneration.

Authors:  Richard A Hickman; Sarah A O'Shea; Mark F Mehler; Wendy K Chung
Journal:  Nat Rev Neurol       Date:  2022-01-05       Impact factor: 42.937

5.  C9orf72 expansion within astrocytes reduces metabolic flexibility in amyotrophic lateral sclerosis.

Authors:  Scott P Allen; Benjamin Hall; Ryan Woof; Laura Francis; Noemi Gatto; Allan C Shaw; Monika Myszczynska; Jordan Hemingway; Ian Coldicott; Amelia Willcock; Lucy Job; Rachel M Hughes; Camilla Boschian; Nadhim Bayatti; Paul R Heath; Oliver Bandmann; Heather Mortiboys; Laura Ferraiuolo; Pamela J Shaw
Journal:  Brain       Date:  2019-12-01       Impact factor: 13.501

6.  Loss of C2orf69 defines a fatal autoinflammatory syndrome in humans and zebrafish that evokes a glycogen-storage-associated mitochondriopathy.

Authors:  Hui Hui Wong; Sze Hwee Seet; Michael Maier; Ayse Gurel; Ricardo Moreno Traspas; Cheryl Lee; Shan Zhang; Beril Talim; Abigail Y T Loh; Crystal Y Chia; Tze Shin Teoh; Danielle Sng; Jarred Rensvold; Sule Unal; Evgenia Shishkova; Ece Cepni; Fatima M Nathan; Fernanda L Sirota; Chao Liang; Nese Yarali; Pelin O Simsek-Kiper; Tadahiro Mitani; Serdar Ceylaner; Ozlem Arman-Bilir; Hamdi Mbarek; Fatma Gumruk; Stephanie Efthymiou; Deniz Uğurlu Çi Men; Danai Georgiadou; Kortessa Sotiropoulou; Henry Houlden; Franziska Paul; Davut Pehlivan; Candice Lainé; Guoliang Chai; Nur Ain Ali; Siew Chin Choo; Soh Sok Keng; Bertrand Boisson; Elanur Yılmaz; Shifeng Xue; Joshua J Coon; Thanh Thao Nguyen Ly; Naser Gilani; Dana Hasbini; Hulya Kayserili; Maha S Zaki; Robert J Isfort; Natalia Ordonez; Kornelia Tripolszki; Peter Bauer; Nima Rezaei; Simin Seyedpour; Ghamar Taj Khotaei; Charles C Bascom; Reza Maroofian; Myriam Chaabouni; Afaf Alsubhi; Wafaa Eyaid; Sedat Işıkay; Joseph G Gleeson; James R Lupski; Jean-Laurent Casanova; David J Pagliarini; Nurten A Akarsu; Sebastian Maurer-Stroh; Arda Cetinkaya; Aida Bertoli-Avella; Ajay S Mathuru; Lena Ho; Frederic A Bard; Bruno Reversade
Journal:  Am J Hum Genet       Date:  2021-05-25       Impact factor: 11.025

Review 7.  Role of Microgliosis and NLRP3 Inflammasome in Parkinson's Disease Pathogenesis and Therapy.

Authors:  Fillipe M de Araújo; Lorena Cuenca-Bermejo; Emiliano Fernández-Villalba; Silvia L Costa; Victor Diogenes A Silva; Maria Trinidad Herrero
Journal:  Cell Mol Neurobiol       Date:  2021-01-02       Impact factor: 5.046

Review 8.  Different Roles of Mitochondria in Cell Death and Inflammation: Focusing on Mitochondrial Quality Control in Ischemic Stroke and Reperfusion.

Authors:  Marianna Carinci; Bianca Vezzani; Simone Patergnani; Peter Ludewig; Katrin Lessmann; Tim Magnus; Ilaria Casetta; Maura Pugliatti; Paolo Pinton; Carlotta Giorgi
Journal:  Biomedicines       Date:  2021-02-09

Review 9.  Mitochondrial Dysfunction as a Driver of Cognitive Impairment in Alzheimer's Disease.

Authors:  Chanchal Sharma; Sehwan Kim; Youngpyo Nam; Un Ju Jung; Sang Ryong Kim
Journal:  Int J Mol Sci       Date:  2021-05-03       Impact factor: 5.923

Review 10.  Interplay between Mitochondrial Protein Import and Respiratory Complexes Assembly in Neuronal Health and Degeneration.

Authors:  Hope I Needs; Margherita Protasoni; Jeremy M Henley; Julien Prudent; Ian Collinson; Gonçalo C Pereira
Journal:  Life (Basel)       Date:  2021-05-11
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