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Literature DB >> 3002586

Small cell carcinoma cell lines contain opioid peptides and receptors.

Abstract

Two human small cell carcinoma cell lines were assayed for total opioid and beta-endorphin-like immunoreactivity. Small cell carcinoma cell line NCI-H146 contained approximately 1.1 pmol/mg protein of total opioid immunoreactivity. This material was similar in size and immunoreactive determinants to C-terminally modified beta-endorphin. Small cell carcinoma cell line NCI-H187 contained approximately 0.2 pmol/mg protein total opioid immunoreactivity, which was of low molecular weight. NCI-H187 also contained approximately 1.2 pmol/mg protein of material similar in size and immunoreactive determinants to beta-lipotropin. The two small cell carcinoma cell lines were also examined for opioid receptors with the use of [3H]-etorphine as ligand. Both cell lines contained between 50 and 100 fmol/mg protein of specific, saturable, high-affinity opioid receptor binding sites. Together, these findings suggest a possible autocrine role for opioids in small cell carcinoma of the lung.

Entities: Chemical Disease Gene Species

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Year: 1986 PMID： 3002586 DOI： 10.1002/1097-0142(19860215)57:4<769::aid-cncr2820570415>3.0.co;2-j

Source DB: PubMed Journal: Cancer ISSN： 0008-543X Impact factor: 6.860

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Cited

12 in total

1. Morphine-induced epidermal growth factor pathway activation in non-small cell lung cancer.

Authors: Naomi Fujioka; Julia Nguyen; Chunsheng Chen; Yunfang Li; Teena Pasrija; Gloria Niehans; Katherine N Johnson; Vinita Gupta; Robert A Kratzke; Kalpna Gupta
Journal: Anesth Analg Date: 2011-10-14 Impact factor: 5.108

Review 2. New perspectives in lung cancer. 2. Growth factors and lung cancer.

Authors: P J Woll
Journal: Thorax Date: 1991-12 Impact factor: 9.139

3. Design, synthesis and evaluation of ¹¹¹In labeled DOTA-conjugated tetrapeptides having high affinity and selectivity for mu opioid receptors.

Authors: John R Lever; Emily A Fergason-Cantrell; Terry L Carmack; Lisa D Watkinson; Fabio Gallazzi
Journal: Nucl Med Biol Date: 2019-03-07 Impact factor: 2.408

Review 9. Opiate Drugs with Abuse Liability Hijack the Endogenous Opioid System to Disrupt Neuronal and Glial Maturation in the Central Nervous System.

Authors: Kurt F Hauser; Pamela E Knapp
Journal: Front Pediatr Date: 2018-01-23 Impact factor: 3.418

10. Activation of delta-opioid receptors inhibits neuronal-like calcium channels and distal steps of Ca(2+)-dependent secretion in human small-cell lung carcinoma cells.

Authors: E Sher; P Cesare; A Codignola; F Clementi; P Tarroni; A Pollo; V Magnelli; E Carbone
Journal: J Neurosci Date: 1996-06-01 Impact factor: 6.167

Small cell carcinoma cell lines contain opioid peptides and receptors.

1. Morphine-induced epidermal growth factor pathway activation in non-small cell lung cancer.

Review 2. New perspectives in lung cancer. 2. Growth factors and lung cancer.

3. Design, synthesis and evaluation of ¹¹¹In labeled DOTA-conjugated tetrapeptides having high affinity and selectivity for mu opioid receptors.

4. Opioid and nicotine receptors affect growth regulation of human lung cancer cell lines.

Review 5. Chronic opioid therapy in long-term cancer survivors.

6. Peptides and growth factors in small cell lung cancer: production, binding sites, and growth effects.

7. Nonconventional opioid binding sites mediate growth inhibitory effects of methadone on human lung cancer cells.

Review 8. Neuropeptide growth factors and cancer.

Review 9. Opiate Drugs with Abuse Liability Hijack the Endogenous Opioid System to Disrupt Neuronal and Glial Maturation in the Central Nervous System.

10. Activation of delta-opioid receptors inhibits neuronal-like calcium channels and distal steps of Ca(2+)-dependent secretion in human small-cell lung carcinoma cells.

Small cell carcinoma cell lines contain opioid peptides and receptors.

1. Morphine-induced epidermal growth factor pathway activation in non-small cell lung cancer.

Review 2. New perspectives in lung cancer. 2. Growth factors and lung cancer.

3. Design, synthesis and evaluation of 111In labeled DOTA-conjugated tetrapeptides having high affinity and selectivity for mu opioid receptors.

4. Opioid and nicotine receptors affect growth regulation of human lung cancer cell lines.

Review 5. Chronic opioid therapy in long-term cancer survivors.

6. Peptides and growth factors in small cell lung cancer: production, binding sites, and growth effects.

7. Nonconventional opioid binding sites mediate growth inhibitory effects of methadone on human lung cancer cells.

Review 8. Neuropeptide growth factors and cancer.

Review 9. Opiate Drugs with Abuse Liability Hijack the Endogenous Opioid System to Disrupt Neuronal and Glial Maturation in the Central Nervous System.

10. Activation of delta-opioid receptors inhibits neuronal-like calcium channels and distal steps of Ca(2+)-dependent secretion in human small-cell lung carcinoma cells.

3. Design, synthesis and evaluation of ¹¹¹In labeled DOTA-conjugated tetrapeptides having high affinity and selectivity for mu opioid receptors.