Literature DB >> 30023996

Novel D-A-D based near-infrared probes for the detection of β-amyloid and Tau fibrils in Alzheimer's disease.

Yuying Li1, Kan Wang, Kaixiang Zhou, Wentao Guo, Bin Dai, Yi Liang, Jiapei Dai, Mengchao Cui.   

Abstract

Novel D-π-A-π-D probes were investigated for the detection of Aβ plaques and NFTs. The probes displayed remarkable optical properties, and DADNIR-2 possessed high affinity towards Tau and Aβ aggregates (Kd = 0.41 nM and 1.04 nM, respectively) with certain selectivity. DADNIR-2 could penetrate the BBB and label Aβ plaques in vivo.

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Year:  2018        PMID： 30023996     DOI： 10.1039/c8cc05259j

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  5 in total

1.  Picomolar-sensitive β-amyloid fibril fluorophores by tailoring the hydrophobicity of biannulated π-elongated dioxaborine-dyes.

Authors:  Jusung An; Peter Verwilst; Hira Aziz; Jinwoo Shin; Sungsu Lim; Ilwha Kim; Yun Kyung Kim; Jong Seung Kim
Journal:  Bioact Mater       Date:  2021-11-09

2.  Rational design and synthesis of a novel BODIPY-based probe for selective imaging of tau tangles in human iPSC-derived cortical neurons.

Authors:  Alessandro Soloperto; Deborah Quaglio; Paola Baiocco; Isabella Romeo; Mattia Mori; Matteo Ardini; Caterina Presutti; Ida Sannino; Silvia Ghirga; Antonia Iazzetti; Rodolfo Ippoliti; Giancarlo Ruocco; Bruno Botta; Francesca Ghirga; Silvia Di Angelantonio; Alberto Boffi
Journal:  Sci Rep       Date:  2022-03-28       Impact factor: 4.379

3.  Portable Vertical Graphene@Au-Based Electrochemical Aptasensing Platform for Point-of-Care Testing of Tau Protein in the Blood.

Authors:  Yibiao Liu; Xingyun Liu; Mifang Li; Qiong Liu; Tailin Xu
Journal:  Biosensors (Basel)       Date:  2022-07-25

4.  Synthesis, optical and electrochemical properties of (D-π)2-type and (D-π)2Ph-type fluorescent dyes.

Authors:  Kosuke Takemura; Kazuki Ohira; Taiki Higashino; Keiichi Imato; Yousuke Ooyama
Journal:  Beilstein J Org Chem       Date:  2022-08-18       Impact factor: 2.544

5.  Sensing Performance Investigations on Two-Photon Fluorescent Probes for Detecting β-Amyloid in Alzheimer's Disease.

Authors:  Yujin Zhang; Ni Luan; Kan Li; Jiancai Leng; Wei Hu
Journal:  Sensors (Basel)       Date:  2020-03-22       Impact factor: 3.576
  5 in total

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