Literature DB >> 30023987

The patients with Peutz-Jeghers syndrome have a high risk of developing cancer.

Cengiz Tavusbay1, Turan Acar1, Haldun Kar1, Kemal Atahan1, Erdinç Kamer1.   

Abstract

Peutz-Jeghers syndrome is an autosomal dominant disorder characterized by mucocutaneous hyperpigmentation, and intestinal and extraintestinal multiple hamartomatous polyps. Development of gastrointestinal and extragastrointestinal cancer risk is markedly increased in patients with Peutz-Jeghers syndrome. We analyzed five patients from two families diagnosed with Peutz-Jeghers syndrome between 1999 and 2012. This study confirms the actual malignancy potency of PJS. Therefore, we suggest a close follow-up of patients with Peutz-Jeghers syndrome for the risk of malignancy.

Entities:  

Keywords:  Peutz-Jeghers syndrome; hamartomatous polyp; intussusception

Year:  2018        PMID： 30023987      PMCID： PMC6048649          DOI： 10.5152/turkjsurg.2017.3241

Source DB:  PubMed          Journal:  Turk J Surg        ISSN： 2564-6850


  9 in total

1.  Fine mapping of a genetic locus for Peutz-Jeghers syndrome on chromosome 19p.

Authors:  C I Amos; D Bali; T J Thiel; J P Anderson; I Gourley; M L Frazier; P M Lynch; M A Luchtefeld; A Young; T J McGarrity; M F Seldin
Journal:  Cancer Res       Date:  1997-09-01       Impact factor: 12.701

Review 2.  Polyposis: the Peutz-Jeghers syndrome.

Authors:  A D Spigelman; P Arese; R K Phillips
Journal:  Br J Surg       Date:  1995-10       Impact factor: 6.939

3.  High proportion of large genomic STK11 deletions in Peutz-Jeghers syndrome.

Authors:  Stefan Aretz; Dietlinde Stienen; Siegfried Uhlhaas; Steffan Loff; Walter Back; Constanze Pagenstecher; D Ross McLeod; Gail E Graham; Elisabeth Mangold; René Santer; Peter Propping; Waltraut Friedl
Journal:  Hum Mutat       Date:  2005-12       Impact factor: 4.878

4.  Very high risk of cancer in familial Peutz-Jeghers syndrome.

Authors:  F M Giardiello; J D Brensinger; A C Tersmette; S N Goodman; G M Petersen; S V Booker; M Cruz-Correa; J A Offerhaus
Journal:  Gastroenterology       Date:  2000-12       Impact factor: 22.682

5.  A serine/threonine kinase gene defective in Peutz-Jeghers syndrome.

Authors:  A Hemminki; D Markie; I Tomlinson; E Avizienyte; S Roth; A Loukola; G Bignell; W Warren; M Aminoff; P Höglund; H Järvinen; P Kristo; K Pelin; M Ridanpää; R Salovaara; T Toro; W Bodmer; S Olschwang; A S Olsen; M R Stratton; A de la Chapelle; L A Aaltonen
Journal:  Nature       Date:  1998-01-08       Impact factor: 49.962

6.  Adenomatous and carcinomatous changes in hamartomatous polyps of the small intestine (Peutz-Jeghers syndrome): report of a case and review of the literature.

Authors:  K H Perzin; M F Bridge
Journal:  Cancer       Date:  1982-03-01       Impact factor: 6.860

7.  Increased risk of cancer in the Peutz-Jeghers syndrome.

Authors:  F M Giardiello; S B Welsh; S R Hamilton; G J Offerhaus; A M Gittelsohn; S V Booker; A J Krush; J H Yardley; G D Luk
Journal:  N Engl J Med       Date:  1987-06-11       Impact factor: 91.245

Review 8.  Peutz-Jeghers syndrome: diagnostic and therapeutic approach.

Authors:  Marcela Kopacova; Ilja Tacheci; Stanislav Rejchrt; Jan Bures
Journal:  World J Gastroenterol       Date:  2009-11-21       Impact factor: 5.742

9.  Increased risk for cancer in patients with the Peutz-Jeghers syndrome.

Authors:  L A Boardman; S N Thibodeau; D J Schaid; N M Lindor; S K McDonnell; L J Burgart; D A Ahlquist; K C Podratz; M Pittelkow; L C Hartmann
Journal:  Ann Intern Med       Date:  1998-06-01       Impact factor: 25.391
  9 in total
  1 in total

1.  Implications of Splicing Alterations in the Onset and Phenotypic Variability of a Family with Subclinical Manifestation of Peutz-Jeghers Syndrome: Bioinformatic and Molecular Evidence.

Authors:  Andrea Cerasuolo; Francesca Cammarota; Francesca Duraturo; Annamaria Staiano; Massimo Martinelli; Erasmo Miele; Paola Izzo; Marina De Rosa
Journal:  Int J Mol Sci       Date:  2020-11-02       Impact factor: 5.923
  1 in total

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