Yelda Dere1, Sümeyye Ekmekçi2, Serkan Çelik1, Özgür İlhan Çelik1, Özcan Dere3, Volkan Karakuş4. 1. Department of Pathology, Muğla Sıtkı Koçman University School of Medicine, Muğla, Turkey. 2. Department of Pathology, Tepecik Training and Research Hospital, İzmir, Turkey. 3. Department of General Surgery, Muğla Sıtkı Koçman University School of Medicine, Muğla, Turkey. 4. Department of Hematology, Muğla Sıtkı Koçman Training and Research Hospital, Muğla, Turkey.
Abstract
OBJECTIVE: In cases presenting with lymphadenopathies (LAP) without a primary focus detected by simple radiological methods, the primary tumor can be diagnosed by a histopathological evaluation of the metastatic lymph nodes. We aimed to discuss the nonhematological malignancies presenting with lymphadenopathies and the histopathological results for primary tumors. MATERIAL AND METHODS: In this retrospective study, cases diagnosed with metastasis in excisional lymph nodes between January 2013 and June 2016 were assessed for a histopathological diagnostic approach. RESULTS: Among 632 lymph node biopsies, a total of 21 cases, involving 12 male and 9 female patients with a mean age of 57.23 y (range, 33-92 y), of nonhematological solid tumors were included. The most common localizations of the involved lymph nodes were inguinal (n=8), axillary (n=6), cervical (n=4), and supraclavicular (n=3) region. The most common primary tumors were malignant melanoma (n=6), breast carcinoma (n=4), ovarian carcinoma (n=2), squamous cell carcinoma (n=2), and germ cell tumor (n=2). Others were papillary thyroid carcinoma, renal cell carcinoma, urothelial carcinoma, prostate adenocarcinoma, and endometrial adenocarcinoma. CONCLUSION: Nonhematological malignancies presenting with lymphadenopathies are one of the most complicated cases for clinicians. The histopathological evaluation of the excisional metastatic lymph node biopsies is an important method because of cost effectiveness and easy applicability.
OBJECTIVE: In cases presenting with lymphadenopathies (LAP) without a primary focus detected by simple radiological methods, the primary tumor can be diagnosed by a histopathological evaluation of the metastatic lymph nodes. We aimed to discuss the nonhematological malignancies presenting with lymphadenopathies and the histopathological results for primary tumors. MATERIAL AND METHODS: In this retrospective study, cases diagnosed with metastasis in excisional lymph nodes between January 2013 and June 2016 were assessed for a histopathological diagnostic approach. RESULTS: Among 632 lymph node biopsies, a total of 21 cases, involving 12 male and 9 female patients with a mean age of 57.23 y (range, 33-92 y), of nonhematological solid tumors were included. The most common localizations of the involved lymph nodes were inguinal (n=8), axillary (n=6), cervical (n=4), and supraclavicular (n=3) region. The most common primary tumors were malignant melanoma (n=6), breast carcinoma (n=4), ovarian carcinoma (n=2), squamous cell carcinoma (n=2), and germ cell tumor (n=2). Others were papillary thyroid carcinoma, renal cell carcinoma, urothelial carcinoma, prostate adenocarcinoma, and endometrial adenocarcinoma. CONCLUSION: Nonhematological malignancies presenting with lymphadenopathies are one of the most complicated cases for clinicians. The histopathological evaluation of the excisional metastatic lymph node biopsies is an important method because of cost effectiveness and easy applicability.
Authors: S G Orel; S P Weinstein; M D Schnall; C A Reynolds; L M Schuchter; D L Fraker; L J Solin Journal: Radiology Date: 1999-08 Impact factor: 11.105
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Authors: Russell Vang; Allen M Gown; Lee-Shu-Fune Wu; Todd S Barry; Darren T Wheeler; Anna Yemelyanova; Jeffrey D Seidman; Brigitte M Ronnett Journal: Mod Pathol Date: 2006-09-15 Impact factor: 7.842