Literature DB >> 30021826

Monitoring Viral Genetic Variation as a Tool To Improve Molecular Diagnostics for Mumps Virus.

Meik Dilcher1, Kevin Barratt1, Jennifer Douglas1, Andrew Strathdee1, Trevor Anderson1, Anja Werno2.   

Abstract

Here, we report how the analysis of viral genetic variation using next-generation sequencing (NGS) can be used as a tool to improve mumps virus diagnostics. Analysis of NGS data from recently circulating mumps virus isolates allowed optimization of the current mumps virus real-time reverse transcription-PCR (RT-PCR) by primer and probe modifications due to nucleotide variations. The modified assay showed a higher efficiency and sensitivity than the previously used CDC protocol for the detection of currently circulating mumps virus strains and could therefore offer better support for outbreak control. The NGS sequence data were also used to make predictions of changes in the hemagglutinin-neuraminidase protein structure that could explain possible immune escape mechanisms.
Copyright © 2018 American Society for Microbiology.

Entities:  

Keywords:  genotype; molecular homology modelling; mumps virus; next-generation sequencing; real-time RT-PCR; vaccines

Mesh：

Substances：

Year:  2018        PMID： 30021826      PMCID： PMC6156297          DOI： 10.1128/JCM.00405-18

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  21 in total

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6.  A Systematic Evaluation of High-Throughput Sequencing Approaches to Identify Low-Frequency Single Nucleotide Variants in Viral Populations.

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