| Literature DB >> 3002156 |
Abstract
Using a specific radioimmunoassay technique it seems that Prostacyclin (PG-I2) has a strong effect on the cyclic nucleotide content of the rat gastric (fundic) mucosa. 1 min after an intragastric application of 100 micrograms/kg PG-I2 the cAMP-content and in the 5th min the cGMP-content showed a highly significant decrease. It seems that the basic mechanism of action of PG-I2 is a typical 'hit and run' effect, acting on the intracellular 'second messenger system'.Entities:
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Year: 1985 PMID： 3002156 DOI： 10.1007/bf01966680
Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299