Literature DB >> 30021173

Cold-Activated Lipid Dynamics in Adipose Tissue Highlights a Role for Cardiolipin in Thermogenic Metabolism.

Matthew D Lynes1, Farnaz Shamsi1, Elahu Gosney Sustarsic2, Luiz O Leiria1, Chih-Hao Wang1, Sheng-Chiang Su1, Tian Lian Huang1, Fei Gao3, Niven R Narain3, Emily Y Chen3, Aaron M Cypess4, Tim J Schulz5, Zachary Gerhart-Hines2, Michael A Kiebish3, Yu-Hua Tseng6.   

Abstract

Thermogenic fat expends energy during cold for temperature homeostasis, and its activity regulates nutrient metabolism and insulin sensitivity. We measured cold-activated lipid landscapes in circulation and in adipose tissue by MS/MSALL shotgun lipidomics. We created an interactive online viewer to visualize the changes of specific lipid species in response to cold. In adipose tissue, among the approximately 1,600 lipid species profiled, we identified the biosynthetic pathway of the mitochondrial phospholipid cardiolipin as coordinately activated in brown and beige fat by cold in wild-type and transgenic mice with enhanced browning of white fat. Together, these data provide a comprehensive lipid bio-signature of thermogenic fat activation in circulation and tissue and suggest pathways regulated by cold exposure.
Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  brown adipose tissue; cardiolipin; lipidomics; thermogenesis; white adipose tissue

Mesh：

Substances：

Year:  2018        PMID： 30021173      PMCID： PMC6117118          DOI： 10.1016/j.celrep.2018.06.073

Source DB:  PubMed          Journal:  Cell Rep            Impact factor:   9.423


  52 in total

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Journal:  Nat Med       Date:  2017-03-27       Impact factor: 53.440

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Authors:  Alexander Bartelt; Oliver T Bruns; Rudolph Reimer; Heinz Hohenberg; Harald Ittrich; Kersten Peldschus; Michael G Kaul; Ulrich I Tromsdorf; Horst Weller; Christian Waurisch; Alexander Eychmüller; Philip L S M Gordts; Franz Rinninger; Karoline Bruegelmann; Barbara Freund; Peter Nielsen; Martin Merkel; Joerg Heeren
Journal:  Nat Med       Date:  2011-01-23       Impact factor: 53.440

5.  A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat.

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Journal:  Cell       Date:  2015-10-22       Impact factor: 41.582

6.  Cold-activated brown adipose tissue in healthy men.

Authors:  Wouter D van Marken Lichtenbelt; Joost W Vanhommerig; Nanda M Smulders; Jamie M A F L Drossaerts; Gerrit J Kemerink; Nicole D Bouvy; Patrick Schrauwen; G J Jaap Teule
Journal:  N Engl J Med       Date:  2009-04-09       Impact factor: 91.245

7.  Muscle and brown adipose tissue fatty acid profiles in cold-exposed rats.

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Journal:  Jpn J Physiol       Date:  1987

8.  Effect of cold stress and norepinephrine on the turnover of phospholipids in brown adipose tissue of the golden hamster (Mesocricetus auratus).

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9.  Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes.

Authors:  Ruidan Xue; Matthew D Lynes; Jonathan M Dreyfuss; Farnaz Shamsi; Tim J Schulz; Hongbin Zhang; Tian Lian Huang; Kristy L Townsend; Yiming Li; Hirokazu Takahashi; Lauren S Weiner; Andrew P White; Maureen S Lynes; Lee L Rubin; Laurie J Goodyear; Aaron M Cypess; Yu-Hua Tseng
Journal:  Nat Med       Date:  2015-06-15       Impact factor: 53.440

10.  Brown adipose tissue improves whole-body glucose homeostasis and insulin sensitivity in humans.

Authors:  Maria Chondronikola; Elena Volpi; Elisabet Børsheim; Craig Porter; Palam Annamalai; Sven Enerbäck; Martin E Lidell; Manish K Saraf; Sebastien M Labbe; Nicholas M Hurren; Christina Yfanti; Tony Chao; Clark R Andersen; Fernando Cesani; Hal Hawkins; Labros S Sidossis
Journal:  Diabetes       Date:  2014-07-23       Impact factor: 9.461
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  27 in total

1.  Phosphocholine accumulation and PHOSPHO1 depletion promote adipose tissue thermogenesis.

Authors:  Mengxi Jiang; Tony E Chavarria; Bingbing Yuan; Harvey F Lodish; Nai-Jia Huang
Journal:  Proc Natl Acad Sci U S A       Date:  2020-06-17       Impact factor: 11.205

2.  Analytical challenges of shotgun lipidomics at different resolution of measurements.

Authors:  Jianing Wang; Xianlin Han
Journal:  Trends Analyt Chem       Date:  2019-10-17       Impact factor: 12.296

3.  Autophagy in Adipose Tissue Physiology and Pathophysiology.

Authors:  Maroua Ferhat; Katsuhiko Funai; Sihem Boudina
Journal:  Antioxid Redox Signal       Date:  2018-11-01       Impact factor: 8.401

4.  Integrated metabolomics reveals altered lipid metabolism in adipose tissue in a model of extreme longevity.

Authors:  Justin Darcy; Yimin Fang; Samuel McFadden; Matthew D Lynes; Luiz O Leiria; Jonathan M Dreyfuss; Valerie Bussburg; Vladimir Tolstikov; Bennett Greenwood; Niven R Narain; Michael A Kiebish; Andrzej Bartke; Yu-Hua Tseng
Journal:  Geroscience       Date:  2020-07-06       Impact factor: 7.713

5.  A Unique Role of Carboxylesterase 3 (Ces3) in β-Adrenergic Signaling-Stimulated Thermogenesis.

Authors:  Li Yang; Xin Li; Hui Tang; Zhanguo Gao; Kangling Zhang; Kai Sun
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Review 6.  Mechanisms of mitochondrial respiratory adaptation.

Authors:  Christopher F Bennett; Pedro Latorre-Muro; Pere Puigserver
Journal:  Nat Rev Mol Cell Biol       Date:  2022-07-08       Impact factor: 94.444

Review 7.  Lipidomics of brown and white adipose tissue: Implications for energy metabolism.

Authors:  Luiz O Leiria; Yu-Hua Tseng
Journal:  Biochim Biophys Acta Mol Cell Biol Lipids       Date:  2020-08-04       Impact factor: 4.698

Review 8.  Lipokines and Thermogenesis.

Authors:  Matthew D Lynes; Sean D Kodani; Yu-Hua Tseng
Journal:  Endocrinology       Date:  2019-10-01       Impact factor: 4.736

9.  Brown Fat-Activating Lipokine 12,13-diHOME in Human Milk Is Associated With Infant Adiposity.

Authors:  Danielle Wolfs; Matthew D Lynes; Yu-Hua Tseng; Stephanie Pierce; Valerie Bussberg; Abena Darkwah; Vladimir Tolstikov; Niven R Narain; Michael C Rudolph; Michael A Kiebish; Ellen W Demerath; David A Fields; Elvira Isganaitis
Journal:  J Clin Endocrinol Metab       Date:  2021-01-23       Impact factor: 5.958

10.  Detouring adrenergic stimulation to induce adipose thermogenesis.

Authors:  Christopher Auger; Shingo Kajimura
Journal:  Nat Rev Endocrinol       Date:  2021-10       Impact factor: 43.330
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