Marc Zanaty1,2,3, Khaled Ajib1,2,3, Mansour Alnazari1,2,3, Elie El Rassy4, Fouad Aoun5, Kevin C Zorn1,2,3, Assaad El-Hakim1,2. 1. Division of Urology, Department of Surgery, Universite de Montreal, Montreal, QC, Canada. 2. Division of Robotic Urology, Department of Surgery, Hôpital Sacré Coeur de Montréal, Montreal, QC, Canada. 3. Division of Robotic Urology, Department of Surgery, Hôpital Saint-Luc, Montreal, QC, Canada. 4. Department of Oncology, Faculty of Medicine, Hotel Dieu de France University Hospital, Saint Joseph University, Beirut, Lebanon. 5. Department of Urology, Faculty of Medicine, Hotel Dieu de France Hospital, Saint Joseph University, Beirut, Lebanon.
Abstract
AIM: Utility of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in predicting biochemical recurrence (BCR) in patients with localized prostate cancer. MATERIALS & METHODS: Retrospective analysis of patients operated by robot-assisted radical prostatectomy. Variables included were: NLR, PLR pre-operative prostate specific antigen, pathological Gleason score, surgical margins status, extracapsular extension, seminal vesical invasion, and lymph node status. RESULTS: Out of 321 patients, no association between NLR or PLR and BCR was detected. Predictors of BCR were pathological Gleason score, extracapsular extension and positive surgical margins. On multivariate analysis, the Gleason Score, extracapsular extension and positive surgical margins remained the only predictors of BCR. CONCLUSION: Neither elevated NLR nor PLR predicted an increased risk of BCR.
AIM: Utility of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in predicting biochemical recurrence (BCR) in patients with localized prostate cancer. MATERIALS & METHODS: Retrospective analysis of patients operated by robot-assisted radical prostatectomy. Variables included were: NLR, PLR pre-operative prostate specific antigen, pathological Gleason score, surgical margins status, extracapsular extension, seminal vesical invasion, and lymph node status. RESULTS: Out of 321 patients, no association between NLR or PLR and BCR was detected. Predictors of BCR were pathological Gleason score, extracapsular extension and positive surgical margins. On multivariate analysis, the Gleason Score, extracapsular extension and positive surgical margins remained the only predictors of BCR. CONCLUSION: Neither elevated NLR nor PLR predicted an increased risk of BCR.
Authors: Carlo A Bravi; Giuseppe Rosiello; Giuseppe Fallara; Emily Vertosick; Amy Tin; Daniel Sjoberg; Marco Bianchi; Elio Mazzone; Alberto Martini; Paolo Dell'oglio; Armando Stabile; Giorgio Gandaglia; Nicola Fossati; Alberto Briganti; Francesco Montorsi; Andrew Vickers Journal: Minerva Urol Nephrol Date: 2020-02-19