S Luo1,2, J Alves1,2, K Hardy2, X Wang3, J Monterosso4,5, A H Xiang3, K A Page1,2,4. 1. Division of Endocrinology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. 2. Diabetes and Obesity Research Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. 3. Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA. 4. Neuroscience Graduate Program, University of Southern California, Los Angeles, CA, USA. 5. Department of Psychology, University of Southern California, Los Angeles, CA, USA.
Abstract
BACKGROUND/ OBJECTIVES: Neuroimaging investigations of brain pathways involved in reward and motivation have primarily focused on adults. This study sought to identify brain responses to visual food cues and explore its relationships with adiposity and sex in pre-pubertal children. METHODS: Brain responses to palatable food vs. non-food cues were measured in 53 children (age: 8.18 ± .66 years; sex: 22 boys, 31 girls) after an overnight fast. Whole-brain analysis (cluster-correction Z > 2.3, P < .05) was performed to examine brain food cue reactivity and its relationships with adiposity and sex. RESULTS: Greater brain activity in response to food vs. non-food cues was observed in regions implicated in reward (orbital frontal cortex, striatum), taste (insula, postcentral gyrus), appetite (hypothalamus), emotion (amygdala), memory (hippocampus), visual processing (occipital cortex) and attention (parietal cortex). A negative association was found between percent body fat and food cue reactivity in the medial prefrontal cortex and lateral orbital frontal cortex adjusting for age and sex. Boys compared with girls had increased food cue reactivity in right hippocampus and visual cortex. CONCLUSIONS: These data suggest that body fat and sex are important moderators of brain food cue reactivity in children.
BACKGROUND/ OBJECTIVES: Neuroimaging investigations of brain pathways involved in reward and motivation have primarily focused on adults. This study sought to identify brain responses to visual food cues and explore its relationships with adiposity and sex in pre-pubertal children. METHODS: Brain responses to palatable food vs. non-food cues were measured in 53 children (age: 8.18 ± .66 years; sex: 22 boys, 31 girls) after an overnight fast. Whole-brain analysis (cluster-correction Z > 2.3, P < .05) was performed to examine brain food cue reactivity and its relationships with adiposity and sex. RESULTS: Greater brain activity in response to food vs. non-food cues was observed in regions implicated in reward (orbital frontal cortex, striatum), taste (insula, postcentral gyrus), appetite (hypothalamus), emotion (amygdala), memory (hippocampus), visual processing (occipital cortex) and attention (parietal cortex). A negative association was found between percent body fat and food cue reactivity in the medial prefrontal cortex and lateral orbital frontal cortex adjusting for age and sex. Boys compared with girls had increased food cue reactivity in right hippocampus and visual cortex. CONCLUSIONS: These data suggest that body fat and sex are important moderators of brain food cue reactivity in children.
Authors: Kristina M Rapuano; Jeremy F Huckins; James D Sargent; Todd F Heatherton; William M Kelley Journal: Cereb Cortex Date: 2015-05-20 Impact factor: 5.357
Authors: Amanda S Bruce; Rebecca J Lepping; Jared M Bruce; J Bradley C Cherry; Laura E Martin; Ann M Davis; William M Brooks; Cary R Savage Journal: J Pediatr Date: 2012-12-01 Impact factor: 4.406
Authors: C J de Groot; E L T van den Akker; E H H M Rings; H A Delemarre-van de Waal; J van der Grond Journal: Pediatr Obes Date: 2016-05-31 Impact factor: 4.000
Authors: Floor van Meer; Laura N van der Laan; Roger A H Adan; Max A Viergever; Paul A M Smeets Journal: Neuroimage Date: 2014-10-05 Impact factor: 6.556
Authors: Anna R Rasmussen; Christine Wohlfahrt-Veje; Katrine Tefre de Renzy-Martin; Casper P Hagen; Jeanette Tinggaard; Annette Mouritsen; Mikkel G Mieritz; Katharina M Main Journal: Pediatrics Date: 2014-12-22 Impact factor: 7.124
Authors: Shan Luo; Brendan Angelo; Ting Chow; John R Monterosso; Anny H Xiang; Paul M Thompson; Kathleen A Page Journal: Brain Imaging Behav Date: 2021-03-18 Impact factor: 3.978
Authors: Shan Luo; Brendan C Angelo; Ting Chow; John R Monterosso; Paul M Thompson; Anny H Xiang; Kathleen A Page Journal: Diabetes Care Date: 2021-04-07 Impact factor: 19.112
Authors: Mimi S Kim; Shan Luo; Anisa Azad; Claire E Campbell; Kimberly Felix; Ryan P Cabeen; Britni R Belcher; Robert Kim; Monica Serrano-Gonzalez; Megan M Herting Journal: Front Hum Neurosci Date: 2020-12-03 Impact factor: 3.169
Authors: Andre K Portella; Afroditi Papantoni; Antoneta T Joseph; Liuyi Chen; Richard S Lee; Patricia P Silveira; Laurette Dube; Susan Carnell Journal: Sci Rep Date: 2021-12-16 Impact factor: 4.379