Nanna Scharff Poulsen1, Julia Rebecka Dahlqvist2, Gitte Hedermann2, Nicoline Løkken2, John Vissing2. 1. Copenhagen Neuromuscular Center, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark. Electronic address: nanna.scharff.poulsen@regionh.dk. 2. Copenhagen Neuromuscular Center, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark.
Abstract
BACKGROUND: The primary disease mechanism underlying mitochondrial myopathies (MM) is impaired energy generation to support muscle endurance. Little is known about muscle contractility before energy becomes deficient during muscle contractions. We investigated muscle contractility in MM to uncover potentially fixed weakness aspects of the disorders. METHODS: Contractility of calf and thigh muscles was investigated by comparing strength with contractile cross-sectional area (CCSA) of the used muscles, as measured by stationary dynamometry and MRI, respectively. RESULTS AND DISCUSSION: Our findings suggest reduced contractile properties in thigh and calf muscles of patients with MM.
BACKGROUND: The primary disease mechanism underlying mitochondrial myopathies (MM) is impaired energy generation to support muscle endurance. Little is known about muscle contractility before energy becomes deficient during muscle contractions. We investigated muscle contractility in MM to uncover potentially fixed weakness aspects of the disorders. METHODS: Contractility of calf and thigh muscles was investigated by comparing strength with contractile cross-sectional area (CCSA) of the used muscles, as measured by stationary dynamometry and MRI, respectively. RESULTS AND DISCUSSION: Our findings suggest reduced contractile properties in thigh and calf muscles of patients with MM.
Authors: Julia R Dahlqvist; Sofie T Oestergaard; Nanna S Poulsen; Kirsten Lykke Knak; Carsten Thomsen; John Vissing Journal: Sci Rep Date: 2019-03-18 Impact factor: 4.379