Chao-Wei Wang1, Lin-Lin Su1, Qiu-Ju Hua2, Ying He1, Yan-Nan Fan1, Ting-Ting Xi3, Bin Yuan1, Yan-Xia Liu4, Si-Bei Ji5. 1. Department of Neurology II, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China; Henan Key Laboratory of Neural Regeneration, Weihui, China. 2. Hospital of Nephrology, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China. 3. Henan Key Laboratory of Neural Regeneration, Weihui, China; Department of Neurology I, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China. 4. Department of General Medical, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China. 5. Department of Neurology II, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China; Henan Key Laboratory of Neural Regeneration, Weihui, China. Electronic address: ballblank@163.com.
Abstract
OBJECTIVE: To investigate the prognostic value of aspirin reaction units (ARU) in a 3-month follow-up study in a cohort of Chinese patients with first-ever ischemic stroke. METHODS: Prospective single-center survey of acute ischemic stroke patients receiving aspirin therapy. Two hundred and seventy-five Chinese patients with first-ever ischemic stroke who previously received aspirin therapy were enrolled. ARU was measured using the VerifyNow system. A cutoff of 550 ARU was used to determine the presence of aspirin resistance (AR). RESULTS: Median age at study entry was 67 years (IQR: 59-75) and 142(51.6%) were male. A total of 52 of 275 enrolled patients (18.9%) were AR. Median regression estimated a statistically significant increase in NIHSS score of 0.033 point for every 1-point increase in ARU (95% CI, 0.024 to 0.068; P < 0.001). The unfavorable outcomes distribution across the ARU quartiles ranged between 11.8% (first quartile) to 64.8% (fourth quartile). After adjusting for other established risk factors, in multivariate models comparing the third and fourth quartiles against the first quartile of the ARU, levels of ARU were associated with unfavorable outcome, and the adjusted risk of unfavorable outcome increased by 145% (OR = 2.45 [95% CI 1.46-3.87], P = 0.011) and 317% (4.17[2.76-6.15], P < 0.001), respectively. Similarly, the adjusted risk of mortality increased by 215% (OR = 3.15 [95% CI 1.98-4.73], P = 0.008) and 429% (5.29[4.02-8.17], P < 0.001), respectively. CONCLUSIONS: The results suggest that AR is a meaningful and independent marker to predict short-term functional outcome in patients with ischemic stroke.
OBJECTIVE: To investigate the prognostic value of aspirin reaction units (ARU) in a 3-month follow-up study in a cohort of Chinese patients with first-ever ischemic stroke. METHODS: Prospective single-center survey of acute ischemic strokepatients receiving aspirin therapy. Two hundred and seventy-five Chinese patients with first-ever ischemic stroke who previously received aspirin therapy were enrolled. ARU was measured using the VerifyNow system. A cutoff of 550 ARU was used to determine the presence of aspirin resistance (AR). RESULTS: Median age at study entry was 67 years (IQR: 59-75) and 142(51.6%) were male. A total of 52 of 275 enrolled patients (18.9%) were AR. Median regression estimated a statistically significant increase in NIHSS score of 0.033 point for every 1-point increase in ARU (95% CI, 0.024 to 0.068; P < 0.001). The unfavorable outcomes distribution across the ARU quartiles ranged between 11.8% (first quartile) to 64.8% (fourth quartile). After adjusting for other established risk factors, in multivariate models comparing the third and fourth quartiles against the first quartile of the ARU, levels of ARU were associated with unfavorable outcome, and the adjusted risk of unfavorable outcome increased by 145% (OR = 2.45 [95% CI 1.46-3.87], P = 0.011) and 317% (4.17[2.76-6.15], P < 0.001), respectively. Similarly, the adjusted risk of mortality increased by 215% (OR = 3.15 [95% CI 1.98-4.73], P = 0.008) and 429% (5.29[4.02-8.17], P < 0.001), respectively. CONCLUSIONS: The results suggest that AR is a meaningful and independent marker to predict short-term functional outcome in patients with ischemic stroke.
Authors: Narayanaswamy Venketasubramanian; Sherwin Joy Agustin; Jorge L Padilla; Maricar P Yumul; Christina Sum; Sze Haur Lee; Kuperan Ponnudurai; Robert N Gan Journal: J Cardiovasc Dev Dis Date: 2022-05-12
Authors: Yaning Li; Yan Wang; Yang Yao; Brian B Griffiths; Liangshu Feng; Tao Tao; Feng Wang; Baohui Xu; Creed M Stary; Heng Zhao Journal: J Immunol Res Date: 2020-08-28 Impact factor: 4.818