PURPOSE: To evaluate visual and retinal changes in patients with bipolar disorder. To analyze the correlation between structural changes and visual function parameters. METHODS: Thirty patients with bipolar disorder and 80 healthy controls underwent visual function evaluation with Early Treatment Diabetic Retinopathy Study charts at 100%, 2.50%, and 1.25% contrast, Pelli-Robson chart, and color vision Farnsworth and Lanthony tests. Analysis of the different retinal layers was performed using Spectralis optical coherence tomography with automated segmentation software. Correlation analysis between structural and functional parameters was conducted. RESULTS: Patients with bipolar disorder presented worse color vision compared with controls (Lanthony's index, P = 0.002). Full macular thickness, the retinal nerve fiber layer (RNFL), ganglion cell layer, and inner plexiform layer were reduced in patients compared with healthy individuals (P < 0.005). The inner nuclear layer was significantly thickened in patients (P < 0.005). Peripapillary RNFL thickness was reduced in all temporal sectors (P < 0.005). Significant correlations were found between visual acuity and the RNFL thickness, the Pelli-Robson score and the inner plexiform layer, and between the Lanthony's color index and the ganglion cell layer thickness. CONCLUSION: Patients with bipolar disorder present quantifiable thinning of the macular RNFL, ganglion cell layer, and inner plexiform layer, as well as in the peripapillary RNFL thickness, and increasing thinning in the inner nuclear layer.
PURPOSE: To evaluate visual and retinal changes inpatients with bipolar disorder. To analyze the correlation between structural changes and visual function parameters. METHODS: Thirty patients with bipolar disorder and 80 healthy controls underwent visual function evaluation with Early Treatment Diabetic Retinopathy Study charts at 100%, 2.50%, and 1.25% contrast, Pelli-Robson chart, and color vision Farnsworth and Lanthony tests. Analysis of the different retinal layers was performed using Spectralis optical coherence tomography with automated segmentation software. Correlation analysis between structural and functional parameters was conducted. RESULTS:Patients with bipolar disorder presented worse color vision compared with controls (Lanthony's index, P = 0.002). Full macular thickness, the retinal nerve fiber layer (RNFL), ganglion cell layer, and inner plexiform layer were reduced in patients compared with healthy individuals (P < 0.005). The inner nuclear layer was significantly thickened in patients (P < 0.005). Peripapillary RNFL thickness was reduced in all temporal sectors (P < 0.005). Significant correlations were found between visual acuity and the RNFL thickness, the Pelli-Robson score and the inner plexiform layer, and between the Lanthony's color index and the ganglion cell layer thickness. CONCLUSION:Patients with bipolar disorder present quantifiable thinning of the macular RNFL, ganglion cell layer, and inner plexiform layer, as well as in the peripapillary RNFL thickness, and increasing thinning in the inner nuclear layer.
Authors: Deepthi Bannai; Paulo Lizano; Megan Kasetty; Olivia Lutz; Victor Zeng; Suraj Sarvode; Leo A Kim; Scot Hill; Carol Tamminga; Brett Clementz; Elliot Gershon; Godfrey Pearlson; John B Miller; Matcheri Keshavan Journal: Psychiatry Res Neuroimaging Date: 2020-02-29 Impact factor: 2.376
Authors: Luciano Boquete; Maria-José Vicente; Juan-Manuel Miguel-Jiménez; Eva-María Sánchez-Morla; Miguel Ortiz; Maria Satue; Elena Garcia-Martin Journal: Int J Clin Health Psychol Date: 2022-02-23
Authors: Michael J McCarthy; John F Gottlieb; Robert Gonzalez; Colleen A McClung; Lauren B Alloy; Sean Cain; Davide Dulcis; Bruno Etain; Benicio N Frey; Corrado Garbazza; Kyle D Ketchesin; Dominic Landgraf; Heon-Jeong Lee; Cynthia Marie-Claire; Robin Nusslock; Alessandra Porcu; Richard Porter; Philipp Ritter; Jan Scott; Daniel Smith; Holly A Swartz; Greg Murray Journal: Bipolar Disord Date: 2021-12-10 Impact factor: 5.345