Patrik Gilje1, Martin Frydland2, John Bro-Jeppesen2, Josef Dankiewicz3, Hans Friberg3, Malin Rundgren3, Yvan Devaux4, Pascal Stammet5, Mariam Al-Mashat6, Jonas Jögi6, Jesper Kjaergaard2, Christian Hassager2, David Erlinge1. 1. a Department of Cardiology, Clinical Sciences , Lund University , Lund , Sweden. 2. b The Heart Centre, Department of Cardiology , Copenhagen University Hospital , Copenhagen , Denmark. 3. c Department of Intensive and Perioperative Care, Clinical Sciences , Lund University , Lund , Sweden. 4. d Cardiovascular Research Unit , Luxembourg Institute of Health , Luxembourg , Luxembourg. 5. e The Medical Department, National Rescue Services , Luxembourg, Luxembourg. 6. f Department of Clinical Physiology, Clinical Sciences , Lund University , Lund , Sweden.
Abstract
BACKGROUND: Data suggests that the plasma levels of the liver-specific miR-122-5p might both be a marker of cardiogenic shock and a prognostic marker of out-of-hospital cardiac arrest (OHCA). Our aim was to characterize plasma miR-122-5p at admission after OHCA and to assess the association between miR-122-5p and relevant clinical factors such all-cause mortality and shock at admission after OHCA. METHODS: In the pilot trial, 10 survivors after OHCA were compared to 10 age- and sex-matched controls. In the main trial, 167 unconscious survivors of OHCA from the Targeted Temperature Management (TTM) trial were included. RESULTS: In the pilot trial, plasma miR-122-5p at admission after OHCA was 400-fold elevated compared to controls. In the main trial, plasma miR-122-5p at admission was independently associated with lactate and bystander cardiopulmonary resuscitation. miR-122-5p at admission was not associated with shock at admission (p = 0.14) or all-cause mortality (p = 0.35). Target temperature (33 °C vs 36 °C) was not associated with miR-122-5p levels at any time point. CONCLUSIONS: After OHCA, miR-122-5p demonstrated a marked acute increase in plasma and was independently associated with lactate and bystander resuscitation. However, miR-122-5p at admission was not associated with all-cause mortality or shock at admission.
BACKGROUND: Data suggests that the plasma levels of the liver-specific miR-122-5p might both be a marker of cardiogenic shock and a prognostic marker of out-of-hospital cardiac arrest (OHCA). Our aim was to characterize plasma miR-122-5p at admission after OHCA and to assess the association between miR-122-5p and relevant clinical factors such all-cause mortality and shock at admission after OHCA. METHODS: In the pilot trial, 10 survivors after OHCA were compared to 10 age- and sex-matched controls. In the main trial, 167 unconscious survivors of OHCA from the Targeted Temperature Management (TTM) trial were included. RESULTS: In the pilot trial, plasma miR-122-5p at admission after OHCA was 400-fold elevated compared to controls. In the main trial, plasma miR-122-5p at admission was independently associated with lactate and bystander cardiopulmonary resuscitation. miR-122-5p at admission was not associated with shock at admission (p = 0.14) or all-cause mortality (p = 0.35). Target temperature (33 °C vs 36 °C) was not associated with miR-122-5p levels at any time point. CONCLUSIONS: After OHCA, miR-122-5p demonstrated a marked acute increase in plasma and was independently associated with lactate and bystander resuscitation. However, miR-122-5p at admission was not associated with all-cause mortality or shock at admission.
Authors: Adeline Boileau; Antonio Salgado Somoza; Josef Dankiewicz; Pascal Stammet; Patrik Gilje; David Erlinge; Christian Hassager; Matthew P Wise; Michael Kuiper; Hans Friberg; Niklas Nielsen; Yvan Devaux Journal: Dis Markers Date: 2019-06-02 Impact factor: 3.434
Authors: Mikko Hänninen; Toni Jäntti; Heli Tolppanen; Heli Segersvärd; Tuukka Tarvasmäki; Johan Lassus; Mélanie Vausort; Yvan Devaux; Alessandro Sionis; Ilkka Tikkanen; Veli-Pekka Harjola; Päivi Lakkisto Journal: Int J Mol Sci Date: 2020-10-26 Impact factor: 5.923