| Literature DB >> 30015484 |
Juha H Siitonen1, Lu Yu1, Jakob Danielsson1, Giovanni Di Gregorio1, Peter Somfai1.
Abstract
A short formal synthesis of ent-Cephalotaxine is achieved. The approach features a new Lewis acid-mediated [2,3]-Stevens rearrangement of N-allylated prolineamide to generate a key quaternary stereogenic center. Additionally, a one-pot Parham-aldol sequence was developed to rapidly assemble two of the four rings in the cephalotaxine core.Entities:
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Year: 2018 PMID： 30015484 DOI： 10.1021/acs.joc.8b01540
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354