Efe Eworuke1, Jacqueline M Major2, Lydia I Gilbert McClain3. 1. Division of Epidemiology II, Office of Pharmacovigilance and Epidemiology, Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, Food and Drug Administration, United States of America. Electronic address: efe.eworuke@fda.hhs.gov. 2. Division of Epidemiology II, Office of Pharmacovigilance and Epidemiology, Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, Food and Drug Administration, United States of America. 3. Division of Pulmonary, Allergy, and Rheumatology Products, Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, United States of America.
Abstract
PURPOSE: To estimate the incidence of Acute Respiratory Distress Syndrome (ARDS) and ARDS-related mortality rates. METHODS: We identified patients with a risk factor for ARDS in the National Inpatient Sample (NIS) (2006-2014). Using survey-weighted descriptive statistics we estimated annual and overall proportions of ARDS cases. RESULTS: From over 69 million discharges, 1,151,969 ARDS discharges and 969,567 ARDS discharges with a risk factor were identified. Sepsis (46.8%), pneumonia (44.9%) and shock (44.4%) were the most common ARDS risk factor. Pancreatitis (3.4%), pulmonary contusion (1.4%) and drowning (0.2%) were the least frequently reported. Incidence rates increased from 180.7 (2006) to 220.8 (2011) and again from 182.8 (2012) to 193.4 (2014). Incidence for pneumonia, shock and sepsis-associated ARDS increased steadily, while transfusion and trauma-associated ARDS declined. Trends for gastric aspiration and pancreatitis-related ARDS remained unchanged. Shock, sepsis and transfusion-associated ARDS had higher mortality rates compared to other factors. Except for transfusion and trauma-associated ARDS, mortality rates for other factors declined. CONCLUSION: Although increasing incidence for ARDS was observed, mortality rates declined for most risk factors. Mortality for transfusion and trauma-associated ARDS increased in the later study period, research is needed to examine reasons for the increasing in-hospital deaths associated with these risk factors. Published by Elsevier Inc.
PURPOSE: To estimate the incidence of Acute Respiratory Distress Syndrome (ARDS) and ARDS-related mortality rates. METHODS: We identified patients with a risk factor for ARDS in the National Inpatient Sample (NIS) (2006-2014). Using survey-weighted descriptive statistics we estimated annual and overall proportions of ARDS cases. RESULTS: From over 69 million discharges, 1,151,969 ARDS discharges and 969,567 ARDS discharges with a risk factor were identified. Sepsis (46.8%), pneumonia (44.9%) and shock (44.4%) were the most common ARDS risk factor. Pancreatitis (3.4%), pulmonary contusion (1.4%) and drowning (0.2%) were the least frequently reported. Incidence rates increased from 180.7 (2006) to 220.8 (2011) and again from 182.8 (2012) to 193.4 (2014). Incidence for pneumonia, shock and sepsis-associated ARDS increased steadily, while transfusion and trauma-associated ARDS declined. Trends for gastric aspiration and pancreatitis-related ARDS remained unchanged. Shock, sepsis and transfusion-associated ARDS had higher mortality rates compared to other factors. Except for transfusion and trauma-associated ARDS, mortality rates for other factors declined. CONCLUSION: Although increasing incidence for ARDS was observed, mortality rates declined for most risk factors. Mortality for transfusion and trauma-associated ARDS increased in the later study period, research is needed to examine reasons for the increasing in-hospital deaths associated with these risk factors. Published by Elsevier Inc.
Authors: V Eric Kerchberger; Julie A Bastarache; Ciara M Shaver; Hiromasa Nagata; J Brennan McNeil; Stuart R Landstreet; Nathan D Putz; Wen-Kuang Yu; Jordan Jesse; Nancy E Wickersham; Tatiana N Sidorova; David R Janz; Chirag R Parikh; Edward D Siew; Lorraine B Ware Journal: JCI Insight Date: 2019-11-01
Authors: Thomas R Martin; Rachel L Zemans; Lorraine B Ware; Eric P Schmidt; David W H Riches; Lisa Bastarache; Carolyn S Calfee; Tushar J Desai; Susanne Herold; Catherine L Hough; Mark R Looney; Michael A Matthay; Nuala Meyer; Samir M Parikh; Troy Stevens; B Taylor Thompson Journal: Am J Respir Cell Mol Biol Date: 2022-09 Impact factor: 7.748