| Literature DB >> 30014698 |
Laura Rodríguez-Pérez1, Javier Ramos-Soriano1, Alfonso Pérez-Sánchez1, Beatriz M Illescas1, Antonio Muñoz1, Joanna Luczkowiak2, Fátima Lasala2, Javier Rojo3, Rafael Delgado2, Nazario Martín1,4.
Abstract
SWCNTs, MWCNTs, and SWCNHs have been employed as virus-mimicking nanocarbon platforms for the multivalent presentation of carbohydrates in an artificial Ebola virus infection model assay. These carbon nanoforms have been chemically modified by the covalent attachment of glycodendrons and glycofullerenes using the CuAAC "click chemistry" approach. This modification dramatically increases the water solubility of these structurally different nanocarbons. Their efficiency in blocking DC-SIGN-mediated viral infection by an artificial Ebola virus has been tested in a cellular experimental assay, finding that glycoconjugates based on MWCNTs functionalized with glycofullerenes are potent inhibitors of viral infection.Entities:
Mesh:
Substances:
Year: 2018 PMID: 30014698 DOI: 10.1021/jacs.8b03847
Source DB: PubMed Journal: J Am Chem Soc ISSN: 0002-7863 Impact factor: 15.419