Literature DB >> 3001465

Dexamethasone suppresses pituitary-adrenal but not behavioral effects of centrally administered CRF.

D R Britton, M Varela, A Garcia, M Rosenthal.   

Abstract

Intracerebral ventricular (icv) administration of corticotropin-releasing factor (CRF) significantly enhances the expression of stress-related behaviors in the rat and also activates the pituitary-adrenal system. The pituitary-adrenal response can be blocked by pretreatment of animals with dexamethasone. The behavioral effects (motor activation, increased grooming and decreased eating) on the other hand are resistant to suppression by dexamethasone. The independence of the behavioral effects from activation of the pituitary-adrenal axis suggests that stress-induced release of CRF could contribute to behavioral alterations even in the presence of high concentrations of endogenous steroids.

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Year:  1986        PMID： 3001465     DOI： 10.1016/0024-3205(86)90305-x

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  12 in total

1.  Stress sensitization of ethanol withdrawal-induced reduction in social interaction: inhibition by CRF-1 and benzodiazepine receptor antagonists and a 5-HT1A-receptor agonist.

Authors:  George R Breese; Darin J Knapp; David H Overstreet
Journal:  Neuropsychopharmacology       Date:  2004-03       Impact factor: 7.853

2.  CRF mediates the anxiogenic and anti-rewarding, but not the anorectic effects of PACAP.

Authors:  Riccardo Dore; Attilio Iemolo; Karen L Smith; Xiaofan Wang; Pietro Cottone; Valentina Sabino
Journal:  Neuropsychopharmacology       Date:  2013-05-09       Impact factor: 7.853

3.  CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors.

Authors:  D W Schulz; R S Mansbach; J Sprouse; J P Braselton; J Collins; M Corman; A Dunaiskis; S Faraci; A W Schmidt; T Seeger; P Seymour; F D Tingley; E N Winston; Y L Chen; J Heym
Journal:  Proc Natl Acad Sci U S A       Date:  1996-09-17       Impact factor: 11.205

4.  Low stress reactivity and neuroendocrine factors in the BTBR T+tf/J mouse model of autism.

Authors:  J L Silverman; M Yang; S M Turner; A M Katz; D B Bell; J I Koenig; J N Crawley
Journal:  Neuroscience       Date:  2010-10-01       Impact factor: 3.590

5.  Brainstem reticulospinal neurons are targets for corticotropin-releasing factor-Induced locomotion in roughskin newts.

Authors:  Catherine S Hubbard; E Kurt Dolence; James D Rose
Journal:  Horm Behav       Date:  2009-12-05       Impact factor: 3.587

Review 6.  Physiological and neurochemical aspects of corticotropin-releasing factor actions in the brain: the role of the locus coeruleus.

Authors:  H Lehnert; C Schulz; K Dieterich
Journal:  Neurochem Res       Date:  1998-08       Impact factor: 3.996

7.  Crossroads of corticotropin releasing hormone, corticosteroids and monoamines. About a biological interface between stress and depression.

Authors:  H. M. Van Praag
Journal:  Neurotox Res       Date:  2002 Aug-Sep       Impact factor: 3.911

8.  Differential blockade of CRF-evoked behaviors by depletion of norepinephrine and serotonin in rats.

Authors:  Owen Howard; Gregory V Carr; Tiffany E Hill; Rita J Valentino; Irwin Lucki
Journal:  Psychopharmacology (Berl)       Date:  2008-05-31       Impact factor: 4.530

9.  Central effects of corticotropin releasing factor (CRF): evidence for similar interactions with environmental novelty and with caffeine.

Authors:  D R Britton; E Indyk
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

10.  Stress and corticotropin-releasing factor potentiate center region activity of mice in an open field.

Authors:  E H Lee; Y P Tang; C Y Chai
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530
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