Literature DB >> 3001363

Cloned long-term cytolytic T-lymphocyte line with specificity for an immediate-early membrane antigen of murine cytomegalovirus.

M J Reddehase, H J Bühring, U H Koszinowski.   

Abstract

Long-term cytolytic T-lymphocyte (CTL) lines that are specific for distinct antigens associated with different phases of the replicative cycle of the murine cytomegalovirus (MCMV) were established by cloning of CTL lines derived from lymph nodes of latently infected BALB/c mice. Two CTL clones were characterized in detail. Both displayed the Lyt-2+, L3T4- surface phenotype, and the recognition of their respective target antigens was class I (DLd) major histocompatibility complex antigen restricted. Clone S1 was specific for a structural antigen of MCMV, and clone IE1 detected an MCMV-specified immediate-early (IE) membrane antigen. Clone IE1 retained lytic activity, antigen specificity, and self-restriction after prolonged propagation in the presence of recombinant human interleukin-2 without restimulation by antigen. This interleukin-2-dependent line of the clone IE1, line IE1-IL, can serve as a reference line for the definition of the antigenic determinant IE1 of an IE membrane antigen.

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Year:  1986        PMID： 3001363      PMCID： PMC252747     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  25 in total

1.  Temporal regulation of herpes simplex virus type 1 transcription: location of transcripts on the viral genome.

Authors:  J B Clements; R J Watson; N M Wilkie
Journal:  Cell       Date:  1977-09       Impact factor: 41.582

Review 2.  MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness.

Authors:  R M Zinkernagel; P C Doherty
Journal:  Adv Immunol       Date:  1979       Impact factor: 3.543

3.  Regulation of herpesvirus macromolecular synthesis. I. Cascade regulation of the synthesis of three groups of viral proteins.

Authors:  R W Honess; B Roizman
Journal:  J Virol       Date:  1974-07       Impact factor: 5.103

4.  Temporal regulation of human cytomegalovirus transcription at immediate early and early times after infection.

Authors:  M W Wathen; D R Thomsen; M F Stinski
Journal:  J Virol       Date:  1981-05       Impact factor: 5.103

5.  Genetic control of the cytotoxic T cell response to SV40 tumor-associated specific antigen.

Authors:  B B Knowles; M Koncar; K Pfizenmaier; D Solter; D P Aden; G Trinchieri
Journal:  J Immunol       Date:  1979-05       Impact factor: 5.422

6.  A herpes simplex virus type 1 function continuously required for early and late virus RNA synthesis.

Authors:  R J Watson; J B Clements
Journal:  Nature       Date:  1980-05-29       Impact factor: 49.962

7.  Cytotoxic monoclonal antibody specific for the Lyt-1.2 antigen.

Authors:  C Mark; F Figueroa; Z A Nagy; J Klein
Journal:  Immunogenetics       Date:  1982       Impact factor: 2.846

8.  Biology of simian virus 40 (SV40) transplantation antigen (TrAg). V In vitro demonstration of SV40 TrAg in SV40 infected nonpermissive mouse cells by the lymphocyte mediated cytotoxicity assay.

Authors:  J Pretell; R S Greenfield; S S Tevethia
Journal:  Virology       Date:  1979-08       Impact factor: 3.616

9.  Qat-4 and Qat-5, new murine T-cell antigens governed by the Tla region and identified by monoclonal antibodies.

Authors:  G J Hämmerling; U Hämmerling; L Flaherty
Journal:  J Exp Med       Date:  1979-07-01       Impact factor: 14.307

10.  Demonstration of multiple antigenic sites of the SV40 transplantation rejection antigen by using cytotoxic T lymphocyte clones.

Authors:  A E Campbell; F L Foley; S S Tevethia
Journal:  J Immunol       Date:  1983-01       Impact factor: 5.422
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  33 in total

1.  Experimental preemptive immunotherapy of murine cytomegalovirus disease with CD8 T-cell lines specific for ppM83 and pM84, the two homologs of human cytomegalovirus tegument protein ppUL83 (pp65).

Authors:  R Holtappels; J Podlech; N K Grzimek; D Thomas; M F Pahl-Seibert; M J Reddehase
Journal:  J Virol       Date:  2001-07       Impact factor: 5.103

2.  Protection against lethal cytomegalovirus infection by a recombinant vaccine containing a single nonameric T-cell epitope.

Authors:  M Del Val; H J Schlicht; H Volkmer; M Messerle; M J Reddehase; U H Koszinowski
Journal:  J Virol       Date:  1991-07       Impact factor: 5.103

Review 3.  CD8 T-cell-based immunotherapy of cytomegalovirus infection: "proof of concept" provided by the murine model.

Authors:  Rafaela Holtappels; Verena Böhm; Jürgen Podlech; Matthias J Reddehase
Journal:  Med Microbiol Immunol       Date:  2008-03-15       Impact factor: 3.402

4.  Cytomegalovirus-specific antibodies to an immediate early antigen and a late membrane antigen and their possible role in controlling secondary cytomegalovirus infection.

Authors:  J van Zanten; M van der Giessen; L H van der Voort; W J van Son; W van der Bij; T H The
Journal:  Clin Exp Immunol       Date:  1991-01       Impact factor: 4.330

5.  Control of murine cytomegalovirus in the lungs: relative but not absolute immunodominance of the immediate-early 1 nonapeptide during the antiviral cytolytic T-lymphocyte response in pulmonary infiltrates.

Authors:  R Holtappels; J Podlech; G Geginat; H P Steffens; D Thomas; M J Reddehase
Journal:  J Virol       Date:  1998-09       Impact factor: 5.103

6.  Generation of specific cytotoxic T cells with a fragment of the Epstein-Barr virus-encoded p63/latent membrane protein.

Authors:  D A Thorley-Lawson; E S Israelsohn
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205

7.  Sequence and structural organization of murine cytomegalovirus immediate-early gene 1.

Authors:  G M Keil; A Ebeling-Keil; U H Koszinowski
Journal:  J Virol       Date:  1987-06       Impact factor: 5.103

8.  The putative natural killer decoy early gene m04 (gp34) of murine cytomegalovirus encodes an antigenic peptide recognized by protective antiviral CD8 T cells.

Authors:  R Holtappels; D Thomas; J Podlech; G Geginat; H P Steffens; M J Reddehase
Journal:  J Virol       Date:  2000-02       Impact factor: 5.103

9.  Sequence homology and immunologic cross-reactivity of human cytomegalovirus with HLA-DR beta chain: a means for graft rejection and immunosuppression.

Authors:  R S Fujinami; J A Nelson; L Walker; M B Oldstone
Journal:  J Virol       Date:  1988-01       Impact factor: 5.103

10.  The three-dimensional structure of an H-2Ld-peptide complex explains the unique interaction of Ld with beta-2 microglobulin and peptide.

Authors:  G K Balendiran; J C Solheim; A C Young; T H Hansen; S G Nathenson; J C Sacchettini
Journal:  Proc Natl Acad Sci U S A       Date:  1997-06-24       Impact factor: 11.205
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