Literature DB >> 30013061

Optical control of L-type Ca2+ channels using a diltiazem photoswitch.

Timm Fehrentz1, Florian M E Huber2,3, Nina Hartrampf2, Tobias Bruegmann4,5, James A Frank2,6, Nicholas H F Fine7,8, Daniela Malan4, Johann G Danzl9,10, Denis B Tikhonov11, Martin Sumser2, Philipp Sasse4, David J Hodson7,8, Boris S Zhorov11,12,13, Nikolaj Klöcker14, Dirk Trauner15,16.   

Abstract

L-type Ca2+ channels (LTCCs) play a crucial role in excitation-contraction coupling and release of hormones from secretory cells. They are targets of antihypertensive and antiarrhythmic drugs such as diltiazem. Here, we present a photoswitchable diltiazem, FHU-779, which can be used to reversibly block endogenous LTCCs by light. FHU-779 is as potent as diltiazem and can be used to place pancreatic β-cell function and cardiac activity under optical control.

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Year:  2018        PMID： 30013061     DOI： 10.1038/s41589-018-0090-8

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


  1 in total

1.  Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.

Authors:  S Grissmer; A N Nguyen; J Aiyar; D C Hanson; R J Mather; G A Gutman; M J Karmilowicz; D D Auperin; K G Chandy
Journal:  Mol Pharmacol       Date:  1994-06       Impact factor: 4.436
  1 in total
  9 in total

1.  Transient Photoinactivation of Cell Membrane Protein Activity without Genetic Modification by Molecular Hyperthermia.

Authors:  Peiyuan Kang; Xiaoqing Li; Yaning Liu; Stephanie I Shiers; Hejian Xiong; Monica Giannotta; Elisabetta Dejana; Theodore John Price; Jaona Randrianalisoa; Steven O Nielsen; Zhenpeng Qin
Journal:  ACS Nano       Date:  2019-10-24       Impact factor: 15.881

Review 2.  Recent advances in bioelectronics chemistry.

Authors:  Yin Fang; Lingyuan Meng; Aleksander Prominski; Erik N Schaumann; Matthew Seebald; Bozhi Tian
Journal:  Chem Soc Rev       Date:  2020-07-16       Impact factor: 54.564

Review 3.  Molecular photoswitches in aqueous environments.

Authors:  Jana Volarić; Wiktor Szymanski; Nadja A Simeth; Ben L Feringa
Journal:  Chem Soc Rev       Date:  2021-11-15       Impact factor: 54.564

Review 4.  Optical control of neuronal ion channels and receptors.

Authors:  Pierre Paoletti; Graham C R Ellis-Davies; Alexandre Mourot
Journal:  Nat Rev Neurosci       Date:  2019-09       Impact factor: 34.870

5.  Reversible Photocontrolled Nanopore Assembly.

Authors:  Natalie L Mutter; Jana Volarić; Wiktor Szymanski; Ben L Feringa; Giovanni Maglia
Journal:  J Am Chem Soc       Date:  2019-08-30       Impact factor: 15.419

6.  Subunit-Specific Photocontrol of Glycine Receptors by Azobenzene-Nitrazepam Photoswitcher.

Authors:  Galyna Maleeva; Alba Nin-Hill; Karin Rustler; Elena Petukhova; Daria Ponomareva; Elvira Mukhametova; Alexandre Mj Gomila; Daniel Wutz; Mercedes Alfonso-Prieto; Burkhard König; Pau Gorostiza; Piotr Bregestovski
Journal:  eNeuro       Date:  2021-01-21

Review 7.  The emergence of molecular systems neuroscience.

Authors:  Yang Shen; Alessandro Luchetti; Giselle Fernandes; Won Do Heo; Alcino J Silva
Journal:  Mol Brain       Date:  2022-01-04       Impact factor: 4.399

Review 8.  Photopharmacology of Ion Channels through the Light of the Computational Microscope.

Authors:  Alba Nin-Hill; Nicolas Pierre Friedrich Mueller; Carla Molteni; Carme Rovira; Mercedes Alfonso-Prieto
Journal:  Int J Mol Sci       Date:  2021-11-08       Impact factor: 5.923

Review 9.  Synergistic Approach of Ultrafast Spectroscopy and Molecular Simulations in the Characterization of Intramolecular Charge Transfer in Push-Pull Molecules.

Authors:  Barbara Patrizi; Concetta Cozza; Adriana Pietropaolo; Paolo Foggi; Mario Siciliani de Cumis
Journal:  Molecules       Date:  2020-01-20       Impact factor: 4.411
  9 in total

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