| Literature DB >> 3001231 |
Abstract
The hippocampal vasopressin receptors have been characterised by measuring the stimulated accumulation of inositol monophosphate in the presence of 10 mM LiCl after hippocampal slices were prelabelled with [3H]inositol. Arginine-vasopressin caused a dose-dependent increase in inositol monophosphate accumulation (ED50 = 7.1 nM). The response was unchanged in the absence of Ca2+ and significantly reduced in the presence of a V1-receptor antagonist. Equimolar oxytocin was ineffective as a stimulus. This suggests that the hippocampal receptors are of the V1 type.Entities:
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Year: 1986 PMID： 3001231 DOI： 10.1111/j.1471-4159.1986.tb13016.x
Source DB: PubMed Journal: J Neurochem ISSN： 0022-3042 Impact factor: 5.372