Literature DB >> 3001022

Isolation and characterization of lon mutants in Salmonella typhimurium.

D Downs, L Waxman, A L Goldberg, J Roth.   

Abstract

In this paper we report the isolation and characterization of lon mutants in Salmonella typhimurium. The mutants were isolated by using positive selection by chlorpromazine resistance. The physiological and biochemical properties of the lon mutants in S. typhimurium are very similar to those of Escherichia coli lon mutants. Mutants altered at this locus contain little or no activity of the ATP-dependent protease La and show a number of pleiotropic phenotypes, including increased production of capsular polysaccharides, increased sensitivity to UV light and other DNA-damaging agents, and a decreased ability to degrade abnormal proteins.

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Year:  1986        PMID： 3001022      PMCID： PMC214388          DOI： 10.1128/jb.165.1.193-197.1986

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  30 in total

1.  Genetic engineering in vivo using translocatable drug-resistance elements. New methods in bacterial genetics.

Authors:  N Kleckner; J Roth; D Botstein
Journal:  J Mol Biol       Date:  1977-10-15       Impact factor: 5.469

2.  Mutation preventing capsular polysaccharide synthesis in Escherichia coli K-12 and its effect on bacteriophage resistance.

Authors:  K L Radke; E C Siegel
Journal:  J Bacteriol       Date:  1971-05       Impact factor: 3.490

3.  Protease La from Escherichia coli hydrolyzes ATP and proteins in a linked fashion.

Authors:  L Waxman; A L Goldberg
Journal:  Proc Natl Acad Sci U S A       Date:  1982-08       Impact factor: 11.205

4.  Mutations in the Ion gene of E. coli K12 phenotypically suppress a mutation in the sigma subunit of RNA polymerase.

Authors:  A D Grossman; R R Burgess; W Walter; C A Gross
Journal:  Cell       Date:  1983-01       Impact factor: 41.582

5.  Studies of the protein encoded by the lon mutation, capR9, in Escherichia coli. A labile form of the ATP-dependent protease La that inhibits the wild type protease.

Authors:  C H Chung; L Waxman; A L Goldberg
Journal:  J Biol Chem       Date:  1983-01-10       Impact factor: 5.157

6.  Studies of the ATP-dependent proteolytic enzyme, protease La, from Escherichia coli.

Authors:  F S Larimore; L Waxman; A L Goldberg
Journal:  J Biol Chem       Date:  1982-04-25       Impact factor: 5.157

7.  Degradation of abnormal proteins in Escherichia coli (protein breakdown-protein structure-mistranslation-amino acid analogs-puromycin).

Authors:  A L Goldberg
Journal:  Proc Natl Acad Sci U S A       Date:  1972-02       Impact factor: 11.205

8.  Phosphatidylinositol turnover in platelet activation; calcium mobilization and protein phosphorylation.

Authors:  K Kaibuchi; K Sano; M Hoshijima; Y Takai; Y Nishizuka
Journal:  Cell Calcium       Date:  1982-10       Impact factor: 6.817

9.  The product of the lon (capR) gene in Escherichia coli is the ATP-dependent protease, protease La.

Authors:  C H Chung; A L Goldberg
Journal:  Proc Natl Acad Sci U S A       Date:  1981-08       Impact factor: 11.205

10.  Protein degradation in E. coli: the lon mutation and bacteriophage lambda N and cII protein stability.

Authors:  S Gottesman; M Gottesman; J E Shaw; M L Pearson
Journal:  Cell       Date:  1981-04       Impact factor: 41.582
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  10 in total

1.  Identification of the proteasome inhibitor MG262 as a potent ATP-dependent inhibitor of the Salmonella enterica serovar Typhimurium Lon protease.

Authors:  Hilary Frase; Jason Hudak; Irene Lee
Journal:  Biochemistry       Date:  2006-07-11       Impact factor: 3.162

Review 2.  Linkage map of Salmonella typhimurium, edition VII.

Authors:  K E Sanderson; J R Roth
Journal:  Microbiol Rev       Date:  1988-12

3.  The ATP-dependent lon protease of Salmonella enterica serovar Typhimurium regulates invasion and expression of genes carried on Salmonella pathogenicity island 1.

Authors:  Akiko Takaya; Toshifumi Tomoyasu; Akane Tokumitsu; Mizue Morioka; Tomoko Yamamoto
Journal:  J Bacteriol       Date:  2002-01       Impact factor: 3.490

4.  Cloning, characterization, and inactivation of the Bacillus brevis lon gene.

Authors:  K Ito; S Udaka; H Yamagata
Journal:  J Bacteriol       Date:  1992-04       Impact factor: 3.490

5.  Cloning, nucleotide sequence, and expression of the Bacillus subtilis lon gene.

Authors:  S Riethdorf; U Völker; U Gerth; A Winkler; S Engelmann; M Hecker
Journal:  J Bacteriol       Date:  1994-11       Impact factor: 3.490

Review 6.  Functional mechanics of the ATP-dependent Lon protease- lessons from endogenous protein and synthetic peptide substrates.

Authors:  Irene Lee; Carolyn K Suzuki
Journal:  Biochim Biophys Acta       Date:  2008-03-05

7.  Evidence for structural conservation of Lon and RcsA.

Authors:  K P Dierksen; J Marks; D D Chen; J E Trempy
Journal:  J Bacteriol       Date:  1994-08       Impact factor: 3.490

8.  Lon, a stress-induced ATP-dependent protease, is critically important for systemic Salmonella enterica serovar typhimurium infection of mice.

Authors:  Akiko Takaya; Masato Suzuki; Hidenori Matsui; Toshifumi Tomoyasu; Hiroshi Sashinami; Akio Nakane; Tomoko Yamamoto
Journal:  Infect Immun       Date:  2003-02       Impact factor: 3.441

Review 9.  Proteases and protein degradation in Escherichia coli.

Authors:  M R Maurizi
Journal:  Experientia       Date:  1992-02-15

10.  Predictable Phenotypes of Antibiotic Resistance Mutations.

Authors:  M Knopp; D I Andersson
Journal:  mBio       Date:  2018-05-15       Impact factor: 7.867
  10 in total

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