Literature DB >> 30009674

An Improved, Chemically Modified RNA Encoding BMP-2 Enhances Osteogenesis In Vitro and In Vivo.

Wen Zhang1,2, Rodolfo E De La Vega3, Michael J Coenen3, Sebastian A Müller3,4, Carlos J Peniche Silva1, Manish K Aneja5, Christian Plank2,5, Martijn van Griensven1,3, Christopher H Evans3, Elizabeth R Balmayor1,3.   

Abstract

IMPACT STATEMENT: The use of chemically modified RNA (cmRNA) with increased stability using translation initiator of short untranslated regions (TISU) offers the prospect of finally allowing us to unlock the potent osteogenic properties of BMP-2 in a clinically expedient manner. As noted, delivery of recombinant BMP-2 protein has had modest clinical efficacy, whereas gene delivery is effective but very difficult to translate into human clinical use. This study shows the great potential of cmRNA encoding BMP-2 with TISU in a long-bone critical-sized rat model.

Entities:  

Keywords:  BMP-2; bone healing; mRNA; modified mRNA; transcript therapy; vascularization

Mesh：

Substances：

Year:  2018        PMID： 30009674     DOI： 10.1089/ten.TEA.2018.0112

Source DB:  PubMed          Journal:  Tissue Eng Part A        ISSN： 1937-3341            Impact factor:   3.845


  10 in total

Review 1.  Gene- and RNAi-activated scaffolds for bone tissue engineering: Current progress and future directions.

Authors:  Noah Z Laird; Timothy M Acri; Kelsie Tingle; Aliasger K Salem
Journal:  Adv Drug Deliv Rev       Date:  2021-05-18       Impact factor: 17.873

Review 2.  Gene therapy for bone healing: lessons learned and new approaches.

Authors:  Rodolfo E De la Vega; Aysegul Atasoy-Zeybek; Joseph A Panos; Martijn VAN Griensven; Christopher H Evans; Elizabeth R Balmayor
Journal:  Transl Res       Date:  2021-05-05       Impact factor: 10.171

Review 3.  Concise Review: Application of Chemically Modified mRNA in Cell Fate Conversion and Tissue Engineering.

Authors:  Zohreh Sadat Badieyan; Todd Evans
Journal:  Stem Cells Transl Med       Date:  2019-03-19       Impact factor: 6.940

4.  BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways.

Authors:  Yingnan Geng; Huichuan Duan; Liang Xu; Nevin Witman; Bingqian Yan; Zheyuan Yu; Huijing Wang; Yao Tan; Liqin Lin; Dong Li; Shanshan Bai; Regina Fritsche-Danielson; Jie Yuan; Kenneth Chien; Min Wei; Wei Fu
Journal:  Commun Biol       Date:  2021-01-19

Review 5.  Designing biomaterials for the delivery of RNA therapeutics to stimulate bone healing.

Authors:  L Andrée; F Yang; R Brock; S C G Leeuwenburgh
Journal:  Mater Today Bio       Date:  2021-03-06

Review 6.  Chemically modified mRNA beyond COVID-19: Potential preventive and therapeutic applications for targeting chronic diseases.

Authors:  Dana Elkhalifa; Menatallah Rayan; Ahmed T Negmeldin; Abdelbary Elhissi; Ashraf Khalil
Journal:  Biomed Pharmacother       Date:  2021-10-28       Impact factor: 6.529

7.  Efficient healing of large osseous segmental defects using optimized chemically modified messenger RNA encoding BMP-2.

Authors:  Rodolfo E De La Vega; Martijn van Griensven; Wen Zhang; Michael J Coenen; Christopher V Nagelli; Joseph A Panos; Carlos J Peniche Silva; Johannes Geiger; Christian Plank; Christopher H Evans; Elizabeth R Balmayor
Journal:  Sci Adv       Date:  2022-02-16       Impact factor: 14.136

Review 8.  A brief review of mRNA therapeutics and delivery for bone tissue engineering.

Authors:  Arun Kumar Rajendran; Sivashanmugam Amirthalingam; Nathaniel S Hwang
Journal:  RSC Adv       Date:  2022-03-22       Impact factor: 3.361

9.  Biomaterial-Mediated Protein Expression Induced by Peptide-mRNA Nanoparticles Embedded in Lyophilized Collagen Scaffolds.

Authors:  Rik Oude Egberink; Helen M Zegelaar; Najoua El Boujnouni; Elly M M Versteeg; Willeke F Daamen; Roland Brock
Journal:  Pharmaceutics       Date:  2022-08-02       Impact factor: 6.525

Review 10.  RNA-based scaffolds for bone regeneration: application and mechanisms of mRNA, miRNA and siRNA.

Authors:  Qiuping Leng; Lini Chen; Yonggang Lv
Journal:  Theranostics       Date:  2020-02-10       Impact factor: 11.556
  10 in total

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