Literature DB >> 30009294

Enhancement in RNase H activity of a DNA/RNA hybrid duplex using artificial cationic oligopeptides.

Rintaro Iwata Hara1, Yusuke Maeda, Haruna Fujimaki, Takeshi Wada.   

Abstract

This study assessed the effects of artificial cationic oligopeptides on a DNA/RNA hybrid duplex. An oligopeptide containing the octamer of l-2,4-diaminobutyric acid (Dab8) was found to enhance both the RNase A resistance and RNase H activity of the DNA/RNA hybrid, which are important for developing nucleic acid drugs.

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Year:  2018        PMID: 30009294     DOI: 10.1039/c8cc04082f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  1 in total

1.  An artificial cationic oligosaccharide combined with phosphorothioate linkages strongly improves siRNA stability.

Authors:  Atsushi Irie; Kazuki Sato; Rintaro Iwata Hara; Takeshi Wada; Futoshi Shibasaki
Journal:  Sci Rep       Date:  2020-09-09       Impact factor: 4.379

  1 in total

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