Haibiao Xie1, Bo Ma2, Qunjun Gao3, Hengji Zhan4, Yuchen Liu4, Zhicong Chen1, Shaobo Ye5, Jianfa Li6, Lin Yao7, Weiren Huang8. 1. Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518039, China; Shantou University Medical College, Shantou 515041, China. 2. Shantou University Medical College, Shantou 515041, China; Department of anesthesiology, Shenzhen Second People's Hospital, Shenzhen 518039, China. 3. Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518039, China; Guangzhou Medical University, Guangzhou 511436, China. 4. Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518039, China. 5. Urology department, Shenzhen Second People's Hospital, Shenzhen 518039, China. 6. Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518039, China; Shantou University Medical College, Shantou 515041, China; Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen 518036, China. Electronic address: lijianfayouxiang@163.com. 7. Department of Urology, Peking University First Hospital, Beijing 100034, China. Electronic address: liuyuchenmdcg@163.com. 8. Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518039, China. Electronic address: pony8980@163.com.
Abstract
BACKGROUND: Colorectal neoplasia differentially expressed (CRNDE), a 1910-nt lncRNA encoded on human chromosome 16, has been found to be involved in various cancers. Nevertheless, the clinical and diagnostic values of CRNDE in tumors still need to be explored. In this review, we aimed to elucidate the clinical role of CRNDE in cancer by searching all correlative literature, and we sequentially explored the association between CRNDE levels and overall survival (OS) or clinicopathological characteristics of cancer. METHODS: We conducted a database search of PubMed, Wanfang Data, Ovid, SinoMed, China National Knowledge Infrastructure, Cochrane Library, and Web of Science (up to January 1, 2018). The pooled odds ratio (OR) and hazard ratio (HR) were used to assess extents of correlation between CRNDE and cancer prognosis. After identification of the inclusion and exclusion criteria, 12 articles including 1361 patients were selected for this review. RESULTS: The results suggested that high levels of CRNDE were highly related to poor OS in tumor patients, with pooled HRs of 2.314 (1.894-2.826, P < .001, fixed-effects model). Likewise, we also found that high CRNDE expression was correlated with high tumor stage [OR: 3.340, 95% confidence interval (CI): 2.417-4.616, P < .001, random-effects model] and lymph node metastasis (OR: 3.027, 95% CI: 2.071-4.425, P = .004, random-effects model). CONCLUSIONS: Our findings demonstrated that CRNDE may modify susceptibility for various cancers and may serve as a new predictive factor for prognosis and diagnosis in different types of cancers.
BACKGROUND:Colorectal neoplasia differentially expressed (CRNDE), a 1910-nt lncRNA encoded on human chromosome 16, has been found to be involved in various cancers. Nevertheless, the clinical and diagnostic values of CRNDE in tumors still need to be explored. In this review, we aimed to elucidate the clinical role of CRNDE in cancer by searching all correlative literature, and we sequentially explored the association between CRNDE levels and overall survival (OS) or clinicopathological characteristics of cancer. METHODS: We conducted a database search of PubMed, Wanfang Data, Ovid, SinoMed, China National Knowledge Infrastructure, Cochrane Library, and Web of Science (up to January 1, 2018). The pooled odds ratio (OR) and hazard ratio (HR) were used to assess extents of correlation between CRNDE and cancer prognosis. After identification of the inclusion and exclusion criteria, 12 articles including 1361 patients were selected for this review. RESULTS: The results suggested that high levels of CRNDE were highly related to poor OS in tumorpatients, with pooled HRs of 2.314 (1.894-2.826, P < .001, fixed-effects model). Likewise, we also found that high CRNDE expression was correlated with high tumor stage [OR: 3.340, 95% confidence interval (CI): 2.417-4.616, P < .001, random-effects model] and lymph node metastasis (OR: 3.027, 95% CI: 2.071-4.425, P = .004, random-effects model). CONCLUSIONS: Our findings demonstrated that CRNDE may modify susceptibility for various cancers and may serve as a new predictive factor for prognosis and diagnosis in different types of cancers.
Authors: Anna Fefilova; Pavel Melnikov; Tatiana Prikazchikova; Tatiana Abakumova; Ilya Kurochkin; Pavel V Mazin; Rustam Ziganshin; Olga Sergeeva; Timofei S Zatsepin Journal: Int J Mol Sci Date: 2020-08-05 Impact factor: 5.923